The rs1634330 Polymorphisms in the SOST Gene Are Associated with Body Composition in Chinese Nuclear Families with Male Offspring
Objective. The purpose of this study was to explore the effect of the SOST gene polymorphisms on body composition in Chinese nuclear families with male offspring. Methods. 1,016 individuals were recruited from 335 Chinese nuclear families with male offspring. The nuclear families consist of at least...
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| Format: | Article |
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Wiley
2021-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2021/6698822 |
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| author | Luyue Qi Lianyong Liu Li Li Weiwei Hu Wenzhen Fu Ji Hu Youjia Xu Zhenlin Zhang |
| author_facet | Luyue Qi Lianyong Liu Li Li Weiwei Hu Wenzhen Fu Ji Hu Youjia Xu Zhenlin Zhang |
| author_sort | Luyue Qi |
| collection | DOAJ |
| description | Objective. The purpose of this study was to explore the effect of the SOST gene polymorphisms on body composition in Chinese nuclear families with male offspring. Methods. 1,016 individuals were recruited from 335 Chinese nuclear families with male offspring. The nuclear families consist of at least one male offspring aged 18 to 44. We genotyped the 10 tagged single-nucleotide polymorphisms (SNPs) in SOST gene (rs7220711, rs865429, rs851057, rs1708635, rs2023794, rs1234612, rs74252774, rs1634330, rs851058, and rs1513670) in all the above people. We used dual-energy X-ray absorptiometry to measure the composition of the human body. The quantitative transmission disequilibrium test (QTDT) was used to analyze the associations of the SNPs with the body composition. Results. QTDT analysis showed that rs1634330 was significantly associated with trunk LM P<0.05. However, haplotypes were not found to be significantly associated with the body composition in the within-family association. The 1000 permutations were consistent with these within-family association results. Conclusions. Our results showed that the genetic variation in the SOST gene may contribute to variations in the body composition of Chinese male offspring. |
| format | Article |
| id | doaj-art-d4298dab5f424c92b91e9cf849bda81c |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-d4298dab5f424c92b91e9cf849bda81c2025-02-03T01:29:19ZengWileyInternational Journal of Endocrinology1687-83371687-83452021-01-01202110.1155/2021/66988226698822The rs1634330 Polymorphisms in the SOST Gene Are Associated with Body Composition in Chinese Nuclear Families with Male OffspringLuyue Qi0Lianyong Liu1Li Li2Weiwei Hu3Wenzhen Fu4Ji Hu5Youjia Xu6Zhenlin Zhang7Shanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Yishan Road 600, Shanghai 200233, ChinaDepartment of Endocrinology, Punan Hospital of Pudong New District, No.279 Linyi Road, Pudong, Shanghai 200125, ChinaShanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Yishan Road 600, Shanghai 200233, ChinaShanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Yishan Road 600, Shanghai 200233, ChinaShanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Yishan Road 600, Shanghai 200233, ChinaDepartment of Endocrinology and Metabolism, The Second Affiliated Hospital of Soochow University, Suzhou 215004, ChinaDepartment of Orthopaedics Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, ChinaShanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Diseases, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Yishan Road 600, Shanghai 200233, ChinaObjective. The purpose of this study was to explore the effect of the SOST gene polymorphisms on body composition in Chinese nuclear families with male offspring. Methods. 1,016 individuals were recruited from 335 Chinese nuclear families with male offspring. The nuclear families consist of at least one male offspring aged 18 to 44. We genotyped the 10 tagged single-nucleotide polymorphisms (SNPs) in SOST gene (rs7220711, rs865429, rs851057, rs1708635, rs2023794, rs1234612, rs74252774, rs1634330, rs851058, and rs1513670) in all the above people. We used dual-energy X-ray absorptiometry to measure the composition of the human body. The quantitative transmission disequilibrium test (QTDT) was used to analyze the associations of the SNPs with the body composition. Results. QTDT analysis showed that rs1634330 was significantly associated with trunk LM P<0.05. However, haplotypes were not found to be significantly associated with the body composition in the within-family association. The 1000 permutations were consistent with these within-family association results. Conclusions. Our results showed that the genetic variation in the SOST gene may contribute to variations in the body composition of Chinese male offspring.http://dx.doi.org/10.1155/2021/6698822 |
| spellingShingle | Luyue Qi Lianyong Liu Li Li Weiwei Hu Wenzhen Fu Ji Hu Youjia Xu Zhenlin Zhang The rs1634330 Polymorphisms in the SOST Gene Are Associated with Body Composition in Chinese Nuclear Families with Male Offspring International Journal of Endocrinology |
| title | The rs1634330 Polymorphisms in the SOST Gene Are Associated with Body Composition in Chinese Nuclear Families with Male Offspring |
| title_full | The rs1634330 Polymorphisms in the SOST Gene Are Associated with Body Composition in Chinese Nuclear Families with Male Offspring |
| title_fullStr | The rs1634330 Polymorphisms in the SOST Gene Are Associated with Body Composition in Chinese Nuclear Families with Male Offspring |
| title_full_unstemmed | The rs1634330 Polymorphisms in the SOST Gene Are Associated with Body Composition in Chinese Nuclear Families with Male Offspring |
| title_short | The rs1634330 Polymorphisms in the SOST Gene Are Associated with Body Composition in Chinese Nuclear Families with Male Offspring |
| title_sort | rs1634330 polymorphisms in the sost gene are associated with body composition in chinese nuclear families with male offspring |
| url | http://dx.doi.org/10.1155/2021/6698822 |
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