Estrogen-induced FXR1 promotes endocrine resistance and bone metastasis in breast cancer via BCL2 and GPX4

Estrogen-induced FXR1 promotes endocrine resistance and bone metastasis in breast cancer via BCL2 and GPX4

Estrogen signaling dysregulation plays a critical role in the development of anti-estrogen resistance and bone metastasis of ER+ mammary carcinoma. Using quantitative proteomic screening, we identified FXR1 as an estrogen-regulated RNA-binding protein associated with anti-estrogen resistance. Mechan...

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Bibliographic Details
Main Authors: Yinzhong Shang, Tingfang Cao, Xin Ma, Le Huang, Mingming Wu, Junchao Xu, Jiarui Wang, Hao Wang, Sheng Wu, Vijay Pandey, Zhengsheng Wu, Weijie Zhang, Peter E. Lobie, Xinghua Han, Tao Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
estrogen
FXR1
apoptosis
ferroptosis
anti-estrogen resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1563353/full
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