The role of acetylation and deacetylation in cancer metabolism
Abstract As a hallmark of cancer, metabolic reprogramming adjusts macromolecular synthesis, energy metabolism and redox homeostasis processes to adapt to and promote the complex biological processes of abnormal growth and proliferation. The complexity of metabolic reprogramming lies in its precise r...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Clinical and Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ctm2.70145 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832586823394656256 |
|---|---|
| author | Cuicui Wang Xiaoxin Ma |
| author_facet | Cuicui Wang Xiaoxin Ma |
| author_sort | Cuicui Wang |
| collection | DOAJ |
| description | Abstract As a hallmark of cancer, metabolic reprogramming adjusts macromolecular synthesis, energy metabolism and redox homeostasis processes to adapt to and promote the complex biological processes of abnormal growth and proliferation. The complexity of metabolic reprogramming lies in its precise regulation by multiple levels and factors, including the interplay of multiple signalling pathways, precise regulation of transcription factors and dynamic adjustments in metabolic enzyme activity. In this complex regulatory network, acetylation and deacetylation, which are important post‐translational modifications, regulate key molecules and processes related to metabolic reprogramming by affecting protein function and stability. Dysregulation of acetylation and deacetylation may alter cancer cell metabolic patterns by affecting signalling pathways, transcription factors and metabolic enzyme activity related to metabolic reprogramming, increasing the susceptibility to rapid proliferation and survival. In this review, we focus on discussing how acetylation and deacetylation regulate cancer metabolism, thereby highlighting the central role of these post‐translational modifications in metabolic reprogramming, and hoping to provide strong support for the development of novel cancer treatment strategies. Key points Protein acetylation and deacetylation are key regulators of metabolic reprogramming in tumour cells. These modifications influence signalling pathways critical for tumour metabolism. They modulate the activity of transcription factors that drive gene expression changes. Metabolic enzymes are also affected, altering cellular metabolism to support tumour growth. |
| format | Article |
| id | doaj-art-d420273075734fe0b8c1d6ca4ebe0abc |
| institution | Kabale University |
| issn | 2001-1326 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Medicine |
| spelling | doaj-art-d420273075734fe0b8c1d6ca4ebe0abc2025-01-25T04:00:38ZengWileyClinical and Translational Medicine2001-13262025-01-01151n/an/a10.1002/ctm2.70145The role of acetylation and deacetylation in cancer metabolismCuicui Wang0Xiaoxin Ma1Department of Obstetrics and Gynecology Shengjing Hospital of China Medical University Shenyang City Liaoning Province ChinaDepartment of Obstetrics and Gynecology Shengjing Hospital of China Medical University Shenyang City Liaoning Province ChinaAbstract As a hallmark of cancer, metabolic reprogramming adjusts macromolecular synthesis, energy metabolism and redox homeostasis processes to adapt to and promote the complex biological processes of abnormal growth and proliferation. The complexity of metabolic reprogramming lies in its precise regulation by multiple levels and factors, including the interplay of multiple signalling pathways, precise regulation of transcription factors and dynamic adjustments in metabolic enzyme activity. In this complex regulatory network, acetylation and deacetylation, which are important post‐translational modifications, regulate key molecules and processes related to metabolic reprogramming by affecting protein function and stability. Dysregulation of acetylation and deacetylation may alter cancer cell metabolic patterns by affecting signalling pathways, transcription factors and metabolic enzyme activity related to metabolic reprogramming, increasing the susceptibility to rapid proliferation and survival. In this review, we focus on discussing how acetylation and deacetylation regulate cancer metabolism, thereby highlighting the central role of these post‐translational modifications in metabolic reprogramming, and hoping to provide strong support for the development of novel cancer treatment strategies. Key points Protein acetylation and deacetylation are key regulators of metabolic reprogramming in tumour cells. These modifications influence signalling pathways critical for tumour metabolism. They modulate the activity of transcription factors that drive gene expression changes. Metabolic enzymes are also affected, altering cellular metabolism to support tumour growth.https://doi.org/10.1002/ctm2.70145acetylationcancerdeacetylationmetabolic reprogramming |
| spellingShingle | Cuicui Wang Xiaoxin Ma The role of acetylation and deacetylation in cancer metabolism Clinical and Translational Medicine acetylation cancer deacetylation metabolic reprogramming |
| title | The role of acetylation and deacetylation in cancer metabolism |
| title_full | The role of acetylation and deacetylation in cancer metabolism |
| title_fullStr | The role of acetylation and deacetylation in cancer metabolism |
| title_full_unstemmed | The role of acetylation and deacetylation in cancer metabolism |
| title_short | The role of acetylation and deacetylation in cancer metabolism |
| title_sort | role of acetylation and deacetylation in cancer metabolism |
| topic | acetylation cancer deacetylation metabolic reprogramming |
| url | https://doi.org/10.1002/ctm2.70145 |
| work_keys_str_mv | AT cuicuiwang theroleofacetylationanddeacetylationincancermetabolism AT xiaoxinma theroleofacetylationanddeacetylationincancermetabolism AT cuicuiwang roleofacetylationanddeacetylationincancermetabolism AT xiaoxinma roleofacetylationanddeacetylationincancermetabolism |