Long-Term Survival and PSA Control with Radiation and Immunotherapy for Node Positive Prostate Cancer
We describe a patient with node positive prostate cancer treated with radiation, androgen deprivation, and immunotherapy with long-term overall survival and PSA control. ELISPOT immunoassay studies demonstrated PSA specific T-cells prior to starting vaccine therapy suggesting that this positive resp...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2009/363914 |
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| _version_ | 1832552462366539776 |
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| author | M. Kamrava Kwong Y. Tsang R. A. Madan A. Kaushal C. N. Coleman J. Gulley |
| author_facet | M. Kamrava Kwong Y. Tsang R. A. Madan A. Kaushal C. N. Coleman J. Gulley |
| author_sort | M. Kamrava |
| collection | DOAJ |
| description | We describe a patient with node positive prostate cancer treated with radiation, androgen deprivation, and immunotherapy with long-term overall survival and PSA control. ELISPOT immunoassay studies demonstrated PSA specific T-cells prior to starting vaccine therapy suggesting that this positive response may be related to an improved antitumor immune response of the patient, increased immunogenicity of the tumor, or decreased activation of immune escape pathways. Further evaluation of therapeutic cancer vaccines in combination with radiation and hormonal therapy in the definitive management of prostate cancer is warranted. |
| format | Article |
| id | doaj-art-d411451655bd494da7bc6f26c7b6f20d |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-d411451655bd494da7bc6f26c7b6f20d2025-02-03T05:58:37ZengWileyClinical and Developmental Immunology1740-25221740-25302009-01-01200910.1155/2009/363914363914Long-Term Survival and PSA Control with Radiation and Immunotherapy for Node Positive Prostate CancerM. Kamrava0Kwong Y. Tsang1R. A. Madan2A. Kaushal3C. N. Coleman4J. Gulley5Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USALaboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USALaboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USARadiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USARadiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USALaboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USAWe describe a patient with node positive prostate cancer treated with radiation, androgen deprivation, and immunotherapy with long-term overall survival and PSA control. ELISPOT immunoassay studies demonstrated PSA specific T-cells prior to starting vaccine therapy suggesting that this positive response may be related to an improved antitumor immune response of the patient, increased immunogenicity of the tumor, or decreased activation of immune escape pathways. Further evaluation of therapeutic cancer vaccines in combination with radiation and hormonal therapy in the definitive management of prostate cancer is warranted.http://dx.doi.org/10.1155/2009/363914 |
| spellingShingle | M. Kamrava Kwong Y. Tsang R. A. Madan A. Kaushal C. N. Coleman J. Gulley Long-Term Survival and PSA Control with Radiation and Immunotherapy for Node Positive Prostate Cancer Clinical and Developmental Immunology |
| title | Long-Term Survival and PSA Control with Radiation and Immunotherapy for Node Positive Prostate Cancer |
| title_full | Long-Term Survival and PSA Control with Radiation and Immunotherapy for Node Positive Prostate Cancer |
| title_fullStr | Long-Term Survival and PSA Control with Radiation and Immunotherapy for Node Positive Prostate Cancer |
| title_full_unstemmed | Long-Term Survival and PSA Control with Radiation and Immunotherapy for Node Positive Prostate Cancer |
| title_short | Long-Term Survival and PSA Control with Radiation and Immunotherapy for Node Positive Prostate Cancer |
| title_sort | long term survival and psa control with radiation and immunotherapy for node positive prostate cancer |
| url | http://dx.doi.org/10.1155/2009/363914 |
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