Gut microbiota-derived metabolites and chronic inflammatory diseases
The gut microbiota, a complex ecosystem of microorganisms, plays an essential role in maintaining immune and metabolic homeostasis. Disruption of this microbial balance, known as dysbiosis, has been increasingly implicated in the pathogenesis of chronic inflammatory conditions, including cardiovascu...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Open Exploration Publishing Inc.
2025-01-01
|
| Series: | Exploration of Medicine |
| Subjects: | |
| Online Access: | https://www.explorationpub.com/uploads/Article/A1001275/1001275.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832586161131880448 |
|---|---|
| author | Alejandra Vargas Benjamin L. Robinson Kevin Houston Ana Rosa Vilela Sangay Michael Saadeh Steve D’Souza David A. Johnson |
| author_facet | Alejandra Vargas Benjamin L. Robinson Kevin Houston Ana Rosa Vilela Sangay Michael Saadeh Steve D’Souza David A. Johnson |
| author_sort | Alejandra Vargas |
| collection | DOAJ |
| description | The gut microbiota, a complex ecosystem of microorganisms, plays an essential role in maintaining immune and metabolic homeostasis. Disruption of this microbial balance, known as dysbiosis, has been increasingly implicated in the pathogenesis of chronic inflammatory conditions, including cardiovascular, gastrointestinal, and autoimmune diseases, as well as metabolic disorders such as diabetes and obesity. A crucial mechanism through which the gut microbiota exerts its effects on host physiology is via the production of bioactive metabolites. These metabolites, including short-chain fatty acids, bile acids, and tryptophan derivatives, are key in modulating immune responses and regulating metabolic functions. Dysbiosis disrupts the production and function of these metabolites, thereby contributing to immune dysregulation, chronic inflammation, and disease progression. This review examines the role of gut microbiota-derived metabolites in chronic inflammatory diseases, with a focus on their immunomodulatory and metabolic effects. A deeper understanding of these mechanisms may open the way for novel therapeutic strategies aimed at restoring immune homeostasis and mitigating the global burden of chronic inflammatory diseases. |
| format | Article |
| id | doaj-art-d40fcf65d989481d904ba8935e0fb5e8 |
| institution | Kabale University |
| issn | 2692-3106 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Medicine |
| spelling | doaj-art-d40fcf65d989481d904ba8935e0fb5e82025-01-26T08:32:27ZengOpen Exploration Publishing Inc.Exploration of Medicine2692-31062025-01-016100127510.37349/emed.2025.1001275Gut microbiota-derived metabolites and chronic inflammatory diseasesAlejandra Vargas0https://orcid.org/0009-0003-7994-1371Benjamin L. Robinson1https://orcid.org/0000-0001-9806-0615Kevin Houston2https://orcid.org/0000-0002-8441-0132Ana Rosa Vilela Sangay3https://orcid.org/0000-0002-0597-0247Michael Saadeh4https://orcid.org/0000-0001-9314-5361Steve D’Souza5https://orcid.org/0000-0003-3772-2616David A. Johnson6https://orcid.org/0000-0002-8737-0711Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA, USADepartment of Internal Medicine, Atrium Health, Charlotte, NC, USADepartment of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USADepartment of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA, USADepartment of Internal Medicine, Case Western Reserve University, Cleveland, OH, USADivision of Gastroenterology and Hepatology, Case Western Reserve University, Cleveland, OH, USADivision of Gastroenterology and Hepatology, Eastern Virginia Medical School, Norfolk, VA, USAThe gut microbiota, a complex ecosystem of microorganisms, plays an essential role in maintaining immune and metabolic homeostasis. Disruption of this microbial balance, known as dysbiosis, has been increasingly implicated in the pathogenesis of chronic inflammatory conditions, including cardiovascular, gastrointestinal, and autoimmune diseases, as well as metabolic disorders such as diabetes and obesity. A crucial mechanism through which the gut microbiota exerts its effects on host physiology is via the production of bioactive metabolites. These metabolites, including short-chain fatty acids, bile acids, and tryptophan derivatives, are key in modulating immune responses and regulating metabolic functions. Dysbiosis disrupts the production and function of these metabolites, thereby contributing to immune dysregulation, chronic inflammation, and disease progression. This review examines the role of gut microbiota-derived metabolites in chronic inflammatory diseases, with a focus on their immunomodulatory and metabolic effects. A deeper understanding of these mechanisms may open the way for novel therapeutic strategies aimed at restoring immune homeostasis and mitigating the global burden of chronic inflammatory diseases.https://www.explorationpub.com/uploads/Article/A1001275/1001275.pdfgut microbiomedysbiosischronic inflammatory diseaseshort-chain fatty acidsimmune modulationtherapeutic implications |
| spellingShingle | Alejandra Vargas Benjamin L. Robinson Kevin Houston Ana Rosa Vilela Sangay Michael Saadeh Steve D’Souza David A. Johnson Gut microbiota-derived metabolites and chronic inflammatory diseases Exploration of Medicine gut microbiome dysbiosis chronic inflammatory disease short-chain fatty acids immune modulation therapeutic implications |
| title | Gut microbiota-derived metabolites and chronic inflammatory diseases |
| title_full | Gut microbiota-derived metabolites and chronic inflammatory diseases |
| title_fullStr | Gut microbiota-derived metabolites and chronic inflammatory diseases |
| title_full_unstemmed | Gut microbiota-derived metabolites and chronic inflammatory diseases |
| title_short | Gut microbiota-derived metabolites and chronic inflammatory diseases |
| title_sort | gut microbiota derived metabolites and chronic inflammatory diseases |
| topic | gut microbiome dysbiosis chronic inflammatory disease short-chain fatty acids immune modulation therapeutic implications |
| url | https://www.explorationpub.com/uploads/Article/A1001275/1001275.pdf |
| work_keys_str_mv | AT alejandravargas gutmicrobiotaderivedmetabolitesandchronicinflammatorydiseases AT benjaminlrobinson gutmicrobiotaderivedmetabolitesandchronicinflammatorydiseases AT kevinhouston gutmicrobiotaderivedmetabolitesandchronicinflammatorydiseases AT anarosavilelasangay gutmicrobiotaderivedmetabolitesandchronicinflammatorydiseases AT michaelsaadeh gutmicrobiotaderivedmetabolitesandchronicinflammatorydiseases AT stevedsouza gutmicrobiotaderivedmetabolitesandchronicinflammatorydiseases AT davidajohnson gutmicrobiotaderivedmetabolitesandchronicinflammatorydiseases |