In-Hospital Mortality of Disseminated Tuberculosis in Patients Infected with the Human Immunodeficiency Virus
Background. Tuberculosis (TB) is a cause of significant morbidity and mortality in patients with AIDS. The goal of our study was to determine predictors of in-hospital mortality in patients with AIDS and disseminated tuberculosis in a middle-income country. Material and Methods. We conducted a retro...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/120278 |
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| author | Rodrigo Pires dos Santos Caroline Deutschendorf Karin Scheid Luciano Zubaran Goldani |
| author_facet | Rodrigo Pires dos Santos Caroline Deutschendorf Karin Scheid Luciano Zubaran Goldani |
| author_sort | Rodrigo Pires dos Santos |
| collection | DOAJ |
| description | Background. Tuberculosis (TB) is a cause of significant morbidity and mortality in patients with AIDS. The goal of our study was to determine predictors of in-hospital mortality in patients with AIDS and disseminated tuberculosis in a middle-income country. Material and Methods. We conducted a retrospective cohort study in a tertiary care center, for patients with AIDS in southern Brazil. From 1996 to 2008, all patients with the diagnosis of disseminated TB were included. Results. Eighty patients were included. In-hospital mortality was 35% (N=28). On multivariate Cox regression analysis, low basal albumin (P<.01) was associated with death, and fever at admission was related to better survival (P<.01). Conclusion. Albumin levels or fever are independent predictors of survival in patients with HIV and disseminated TB. They can serve as indirect markers of immunodeficiency in patients with disseminated TB and AIDS. |
| format | Article |
| id | doaj-art-d40d5eaeab664185b3582c826affde65 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-d40d5eaeab664185b3582c826affde652025-02-03T05:58:28ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/120278120278In-Hospital Mortality of Disseminated Tuberculosis in Patients Infected with the Human Immunodeficiency VirusRodrigo Pires dos Santos0Caroline Deutschendorf1Karin Scheid2Luciano Zubaran Goldani3Infectious Disease Service, Hospital de Clínicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), 90035-003, Porto Alegre, RS, BrazilInfectious Disease Service, Hospital de Clínicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), 90035-003, Porto Alegre, RS, BrazilInfectious Disease Service, Hospital de Clínicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), 90035-003, Porto Alegre, RS, BrazilInfectious Disease Service, Hospital de Clínicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), 90035-003, Porto Alegre, RS, BrazilBackground. Tuberculosis (TB) is a cause of significant morbidity and mortality in patients with AIDS. The goal of our study was to determine predictors of in-hospital mortality in patients with AIDS and disseminated tuberculosis in a middle-income country. Material and Methods. We conducted a retrospective cohort study in a tertiary care center, for patients with AIDS in southern Brazil. From 1996 to 2008, all patients with the diagnosis of disseminated TB were included. Results. Eighty patients were included. In-hospital mortality was 35% (N=28). On multivariate Cox regression analysis, low basal albumin (P<.01) was associated with death, and fever at admission was related to better survival (P<.01). Conclusion. Albumin levels or fever are independent predictors of survival in patients with HIV and disseminated TB. They can serve as indirect markers of immunodeficiency in patients with disseminated TB and AIDS.http://dx.doi.org/10.1155/2011/120278 |
| spellingShingle | Rodrigo Pires dos Santos Caroline Deutschendorf Karin Scheid Luciano Zubaran Goldani In-Hospital Mortality of Disseminated Tuberculosis in Patients Infected with the Human Immunodeficiency Virus Clinical and Developmental Immunology |
| title | In-Hospital Mortality of Disseminated Tuberculosis in Patients Infected with the Human Immunodeficiency Virus |
| title_full | In-Hospital Mortality of Disseminated Tuberculosis in Patients Infected with the Human Immunodeficiency Virus |
| title_fullStr | In-Hospital Mortality of Disseminated Tuberculosis in Patients Infected with the Human Immunodeficiency Virus |
| title_full_unstemmed | In-Hospital Mortality of Disseminated Tuberculosis in Patients Infected with the Human Immunodeficiency Virus |
| title_short | In-Hospital Mortality of Disseminated Tuberculosis in Patients Infected with the Human Immunodeficiency Virus |
| title_sort | in hospital mortality of disseminated tuberculosis in patients infected with the human immunodeficiency virus |
| url | http://dx.doi.org/10.1155/2011/120278 |
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