Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity
Cancer stem cell population is a subset of cells capable of dictating invasion, metastasis, heterogeneity, and therapeutic resistance in tumours. Eradication of this rare population is a new insight in cancer treatment. However, prospective identification, characterization, and isolation of these CS...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/708036 |
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| author | Appalaraju Jaggupilli Eyad Elkord |
| author_facet | Appalaraju Jaggupilli Eyad Elkord |
| author_sort | Appalaraju Jaggupilli |
| collection | DOAJ |
| description | Cancer stem cell population is a subset of cells capable of dictating invasion, metastasis, heterogeneity, and therapeutic resistance in tumours. Eradication of this rare population is a new insight in cancer treatment. However, prospective identification, characterization, and isolation of these CSCs have been a major challenge. Many studies were performed on surface markers for potential identification and isolation of CSCs. Lack of universal expression of surface markers limits their usage and no best combination of markers has yet been confirmed to identify CSCs capable of initiating and metastasizing tumours. CD44, a hyaluronic acid receptor, is one of the most commonly studied surface markers, which is expressed by almost every tumour cell. CD24, a heat stable antigen, is another surface marker expressed in many tumour types. However, their expression and prognostic value in isolating CSCs are still an enduring ambiguity. In this critical review, we assess the role of CD44 and CD24 in tumour initiation, development, and metastasis. We mainly focus on analysing the significance of CD44 and CD24 as CSC surface markers in combination or with other putative markers in different types of cancer. |
| format | Article |
| id | doaj-art-d40cb2189c924ec08cb5e5bf75388f72 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-d40cb2189c924ec08cb5e5bf75388f722025-02-03T01:00:49ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/708036708036Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring AmbiguityAppalaraju Jaggupilli0Eyad Elkord1Biomedical Research Centre, School of Environment & Life Sciences, University of Salford, Salford M5 4WT, UKBiomedical Research Centre, School of Environment & Life Sciences, University of Salford, Salford M5 4WT, UKCancer stem cell population is a subset of cells capable of dictating invasion, metastasis, heterogeneity, and therapeutic resistance in tumours. Eradication of this rare population is a new insight in cancer treatment. However, prospective identification, characterization, and isolation of these CSCs have been a major challenge. Many studies were performed on surface markers for potential identification and isolation of CSCs. Lack of universal expression of surface markers limits their usage and no best combination of markers has yet been confirmed to identify CSCs capable of initiating and metastasizing tumours. CD44, a hyaluronic acid receptor, is one of the most commonly studied surface markers, which is expressed by almost every tumour cell. CD24, a heat stable antigen, is another surface marker expressed in many tumour types. However, their expression and prognostic value in isolating CSCs are still an enduring ambiguity. In this critical review, we assess the role of CD44 and CD24 in tumour initiation, development, and metastasis. We mainly focus on analysing the significance of CD44 and CD24 as CSC surface markers in combination or with other putative markers in different types of cancer.http://dx.doi.org/10.1155/2012/708036 |
| spellingShingle | Appalaraju Jaggupilli Eyad Elkord Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity Clinical and Developmental Immunology |
| title | Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity |
| title_full | Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity |
| title_fullStr | Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity |
| title_full_unstemmed | Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity |
| title_short | Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity |
| title_sort | significance of cd44 and cd24 as cancer stem cell markers an enduring ambiguity |
| url | http://dx.doi.org/10.1155/2012/708036 |
| work_keys_str_mv | AT appalarajujaggupilli significanceofcd44andcd24ascancerstemcellmarkersanenduringambiguity AT eyadelkord significanceofcd44andcd24ascancerstemcellmarkersanenduringambiguity |