Hemoglobin Sunshine Seth: A Case Report of Low-Oxygen-Affinity Hemoglobinopathy
Pulse oximetry is routinely used in the newborn nursery for clinical monitoring and to detect critical congenital heart disease. The differential diagnoses for reduced peripheral oxygen saturation in an infant include congenital heart disease, respiratory distress syndrome, transient tachypnea of th...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2020/2853531 |
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| author | Leah S. Heidenreich Jennifer L. Oliveira Peter J. Holmberg Vilmarie Rodriguez |
| author_facet | Leah S. Heidenreich Jennifer L. Oliveira Peter J. Holmberg Vilmarie Rodriguez |
| author_sort | Leah S. Heidenreich |
| collection | DOAJ |
| description | Pulse oximetry is routinely used in the newborn nursery for clinical monitoring and to detect critical congenital heart disease. The differential diagnoses for reduced peripheral oxygen saturation in an infant include congenital heart disease, respiratory distress syndrome, transient tachypnea of the newborn, persistent pulmonary hypertension of the newborn, meconium aspiration syndrome, pneumonia, pneumothorax, and sepsis. The diagnostic evaluation for neonatal hypoxemia can be invasive and expensive. When this evaluation is unrevealing, other interventions may be tried without clear benefit to the patient, including, but not limited to, supplemental oxygen. Therefore, it is important to consider alternative, albeit rare, diagnoses, including hemoglobinopathies with abnormal oxygen binding properties. Mutations in the structure of alpha- and beta-globin chains can alter the affinity of hemoglobin for oxygen, and changes in oxygen affinity may result in changes in the oxygen saturation detected by pulse oximetry. These changes may or may not be of clinical significance. This case report describes Hemoglobin Sunshine Seth, a rare low-oxygen-affinity hemoglobin variant presenting as reduced peripheral oxygen saturation in an otherwise well-appearing infant male. |
| format | Article |
| id | doaj-art-d3d7d5fb23b046cabc949ba826bf810a |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-d3d7d5fb23b046cabc949ba826bf810a2025-02-03T01:27:04ZengWileyCase Reports in Pediatrics2090-68032090-68112020-01-01202010.1155/2020/28535312853531Hemoglobin Sunshine Seth: A Case Report of Low-Oxygen-Affinity HemoglobinopathyLeah S. Heidenreich0Jennifer L. Oliveira1Peter J. Holmberg2Vilmarie Rodriguez3Mayo Clinic Children’s Center, Mayo Clinic, Rochester, Minnesota, USADivision of Hematopathology, Mayo Clinic, Rochester, Minnesota, USAMayo Clinic Children’s Center, Mayo Clinic, Rochester, Minnesota, USAMayo Clinic Children’s Center, Mayo Clinic, Rochester, Minnesota, USAPulse oximetry is routinely used in the newborn nursery for clinical monitoring and to detect critical congenital heart disease. The differential diagnoses for reduced peripheral oxygen saturation in an infant include congenital heart disease, respiratory distress syndrome, transient tachypnea of the newborn, persistent pulmonary hypertension of the newborn, meconium aspiration syndrome, pneumonia, pneumothorax, and sepsis. The diagnostic evaluation for neonatal hypoxemia can be invasive and expensive. When this evaluation is unrevealing, other interventions may be tried without clear benefit to the patient, including, but not limited to, supplemental oxygen. Therefore, it is important to consider alternative, albeit rare, diagnoses, including hemoglobinopathies with abnormal oxygen binding properties. Mutations in the structure of alpha- and beta-globin chains can alter the affinity of hemoglobin for oxygen, and changes in oxygen affinity may result in changes in the oxygen saturation detected by pulse oximetry. These changes may or may not be of clinical significance. This case report describes Hemoglobin Sunshine Seth, a rare low-oxygen-affinity hemoglobin variant presenting as reduced peripheral oxygen saturation in an otherwise well-appearing infant male.http://dx.doi.org/10.1155/2020/2853531 |
| spellingShingle | Leah S. Heidenreich Jennifer L. Oliveira Peter J. Holmberg Vilmarie Rodriguez Hemoglobin Sunshine Seth: A Case Report of Low-Oxygen-Affinity Hemoglobinopathy Case Reports in Pediatrics |
| title | Hemoglobin Sunshine Seth: A Case Report of Low-Oxygen-Affinity Hemoglobinopathy |
| title_full | Hemoglobin Sunshine Seth: A Case Report of Low-Oxygen-Affinity Hemoglobinopathy |
| title_fullStr | Hemoglobin Sunshine Seth: A Case Report of Low-Oxygen-Affinity Hemoglobinopathy |
| title_full_unstemmed | Hemoglobin Sunshine Seth: A Case Report of Low-Oxygen-Affinity Hemoglobinopathy |
| title_short | Hemoglobin Sunshine Seth: A Case Report of Low-Oxygen-Affinity Hemoglobinopathy |
| title_sort | hemoglobin sunshine seth a case report of low oxygen affinity hemoglobinopathy |
| url | http://dx.doi.org/10.1155/2020/2853531 |
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