High glucose promotes macrophage switching to the M1 phenotype via the downregulation of STAT-3 mediated autophagy.

High glucose promotes macrophage switching to the M1 phenotype via the downregulation of STAT-3 mediated autophagy.

<h4>Aim</h4>Imbalanced M1/M2 macrophage phenotype activation is a key point in diabetic kidney disease (DKD). Macrophages mainly exhibit the M1 phenotype, which contributes to inflammation and fibrosis in DKD. Studies have indicated that autophagy plays an important role in M1/M2 activat...

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Main Authors: Yu Zhao, Yuteng Jiang, Fengmei Wang, Li Sun, Mengyuan Ding, Liyuan Zhang, Beibei Wu, Xiaoliang Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0314974
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