Cardiovascular Diseases in Public Health: Chromosomal Abnormalities in Congenital Heart Disease Causing Sudden Cardiac Death in Children
Chromosomal abnormalities (CAs) are changes in the number or structure of chromosomes, manifested as alterations in the total number of chromosomes or as structural abnormalities involving the loss, duplication, or rearrangement of chromosomal segments. CAs can be inherited or can occur spontaneousl...
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MDPI AG
2024-12-01
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| author | Cecilia Salzillo Marco La Verde Amalia Imparato Rossella Molitierno Stefano Lucà Francesca Pagliuca Andrea Marzullo |
| author_facet | Cecilia Salzillo Marco La Verde Amalia Imparato Rossella Molitierno Stefano Lucà Francesca Pagliuca Andrea Marzullo |
| author_sort | Cecilia Salzillo |
| collection | DOAJ |
| description | Chromosomal abnormalities (CAs) are changes in the number or structure of chromosomes, manifested as alterations in the total number of chromosomes or as structural abnormalities involving the loss, duplication, or rearrangement of chromosomal segments. CAs can be inherited or can occur spontaneously, leading to congenital malformations and genetic diseases. CAs associated with cardiovascular diseases cause structural or functional alterations of the heart, affecting the cardiac chambers, valves, coronary arteries, aorta, and cardiac conduction, thus increasing the likelihood of arrhythmias, cardiac arrest, and sudden cardiac death (SCD). An early diagnosis and the adequate management of chromosomal abnormalities associated with cardiovascular diseases are essential to prevent SCD, which is a serious public health problem today. In our review, we analyzed the structural and functional CAs responsible for congenital heart disease (CHD) that increase the risk of SCD and analyzed the prevention strategies to be implemented to reduce SCD. |
| format | Article |
| id | doaj-art-d3cdb66b8e7e4b0b8376d4a5a053d3a2 |
| institution | DOAJ |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj-art-d3cdb66b8e7e4b0b8376d4a5a053d3a22025-08-20T02:43:46ZengMDPI AGMedicina1010-660X1648-91442024-12-016012197610.3390/medicina60121976Cardiovascular Diseases in Public Health: Chromosomal Abnormalities in Congenital Heart Disease Causing Sudden Cardiac Death in ChildrenCecilia Salzillo0Marco La Verde1Amalia Imparato2Rossella Molitierno3Stefano Lucà4Francesca Pagliuca5Andrea Marzullo6PhD Course in Public Health, Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyPhD Course in Public Health, Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyPathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyPathology Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari “Aldo Moro”, 70121 Bari, ItalyChromosomal abnormalities (CAs) are changes in the number or structure of chromosomes, manifested as alterations in the total number of chromosomes or as structural abnormalities involving the loss, duplication, or rearrangement of chromosomal segments. CAs can be inherited or can occur spontaneously, leading to congenital malformations and genetic diseases. CAs associated with cardiovascular diseases cause structural or functional alterations of the heart, affecting the cardiac chambers, valves, coronary arteries, aorta, and cardiac conduction, thus increasing the likelihood of arrhythmias, cardiac arrest, and sudden cardiac death (SCD). An early diagnosis and the adequate management of chromosomal abnormalities associated with cardiovascular diseases are essential to prevent SCD, which is a serious public health problem today. In our review, we analyzed the structural and functional CAs responsible for congenital heart disease (CHD) that increase the risk of SCD and analyzed the prevention strategies to be implemented to reduce SCD.https://www.mdpi.com/1648-9144/60/12/1976chromosomal abnormalitiesgenetic disorderscongenital heart diseasesudden cardiac deathcardiovascular diseasespublic health |
| spellingShingle | Cecilia Salzillo Marco La Verde Amalia Imparato Rossella Molitierno Stefano Lucà Francesca Pagliuca Andrea Marzullo Cardiovascular Diseases in Public Health: Chromosomal Abnormalities in Congenital Heart Disease Causing Sudden Cardiac Death in Children Medicina chromosomal abnormalities genetic disorders congenital heart disease sudden cardiac death cardiovascular diseases public health |
| title | Cardiovascular Diseases in Public Health: Chromosomal Abnormalities in Congenital Heart Disease Causing Sudden Cardiac Death in Children |
| title_full | Cardiovascular Diseases in Public Health: Chromosomal Abnormalities in Congenital Heart Disease Causing Sudden Cardiac Death in Children |
| title_fullStr | Cardiovascular Diseases in Public Health: Chromosomal Abnormalities in Congenital Heart Disease Causing Sudden Cardiac Death in Children |
| title_full_unstemmed | Cardiovascular Diseases in Public Health: Chromosomal Abnormalities in Congenital Heart Disease Causing Sudden Cardiac Death in Children |
| title_short | Cardiovascular Diseases in Public Health: Chromosomal Abnormalities in Congenital Heart Disease Causing Sudden Cardiac Death in Children |
| title_sort | cardiovascular diseases in public health chromosomal abnormalities in congenital heart disease causing sudden cardiac death in children |
| topic | chromosomal abnormalities genetic disorders congenital heart disease sudden cardiac death cardiovascular diseases public health |
| url | https://www.mdpi.com/1648-9144/60/12/1976 |
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