Impact of modulating leptin sensitivity on the transcriptomic profile of adult-derived hypothalamic mouse neurons

Impact of modulating leptin sensitivity on the transcriptomic profile of adult-derived hypothalamic mouse neurons

The modulation of leptin sensitivity in hypothalamic neurons plays a crucial role in metabolic regulation and the development of obesity. Three distinct approaches, exposure to leptin (LEPA), administration of leptin antagonist (LANTA), and treatment with palmitate (PA), were explored in this study...

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Bibliographic Details
Main Authors: Ewa Ocłoń, Artur Gurgul, Tomasz Szmatoła, Igor Jasielczuk, Miroslaw Kucharski, Joanna Zubel-Łojek, Dorota Anna Zieba
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
leptin
hypothalamic neurons
palmitic acid
leptin resistance
inflammation
RNA-seq and Traf5
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1518737/full
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