Long-Term and Short-Term Effects of Hemodialysis on Liver Function Evaluated Using the Galactose Single-Point Test
Aim. The galactose single-point (GSP) test assesses functioning liver mass by measuring the galactose concentration in the blood 1 hour after its administration. The purpose of this study was to investigate the impact of hemodialysis (HD) on short-term and long-term liver function by use of GSP test...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/260939 |
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| author | Yi-Chou Hou Wen-Chih Liu Min-Tser Liao Kuo-Cheng Lu Lan Lo Heng-Chih Pan Chia-Chao Wu Oliver Yoa-Pu Hu Hung-Shang Tang |
| author_facet | Yi-Chou Hou Wen-Chih Liu Min-Tser Liao Kuo-Cheng Lu Lan Lo Heng-Chih Pan Chia-Chao Wu Oliver Yoa-Pu Hu Hung-Shang Tang |
| author_sort | Yi-Chou Hou |
| collection | DOAJ |
| description | Aim. The galactose single-point (GSP) test assesses functioning liver mass by measuring the galactose concentration in the blood 1 hour after its administration. The purpose of this study was to investigate the impact of hemodialysis (HD) on short-term and long-term liver function by use of GSP test. Methods. Seventy-four patients on maintenance HD (46 males and 28 females, 60.38 ± 11.86 years) with a mean time on HD of 60.77 ± 48.31 months were studied. The GSP values were compared in two groups: (1) before and after single session HD, and (2) after one year of maintenance HD. Results. Among the 74 HD patient, only the post-HD Cr levels and years on dialysis were significantly correlated with GSP values (r=0.280, P<0.05 and r=-0.240, P<0.05, resp.). 14 of 74 patients were selected for GSP evaluation before and after a single HD session, and the hepatic clearance of galactose was similar (pre-HD 410 ± 254 g/mL, post-HD 439 ± 298 g/mL, P=0.49). GSP values decreased from 420.20 ± 175.26 g/mL to 383.40 ± 153.97 g/mL after 1 year maintenance HD in other 15 patients (mean difference: 19.00 ± 37.66 g/mL, P<0.05). Conclusions. Patients on maintenance HD for several years may experience improvement of their liver function. However, a single HD session does not affect liver function significantly as assessed by the GSP test. Since the metabolism of galactose is dependent on liver blood flow and hepatic functional mass, further studies are needed. |
| format | Article |
| id | doaj-art-d3be0011c0024b96a8ae2e532d583dff |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-d3be0011c0024b96a8ae2e532d583dff2025-02-03T01:12:56ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/260939260939Long-Term and Short-Term Effects of Hemodialysis on Liver Function Evaluated Using the Galactose Single-Point TestYi-Chou Hou0Wen-Chih Liu1Min-Tser Liao2Kuo-Cheng Lu3Lan Lo4Heng-Chih Pan5Chia-Chao Wu6Oliver Yoa-Pu Hu7Hung-Shang Tang8Department of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, 362 Chung-Cheng Road, Hsin-Tien District, New Taipei City 23148, TaiwanDepartment of Internal Medicine, Cardinal Tien Hospital, Yonghe Branch, New Taipei City 23445, TaiwanDepartment of Pediatrics, Taoyuan Armed Forces General Hospital, Taoyuan 325, TaiwanDepartment of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, 362 Chung-Cheng Road, Hsin-Tien District, New Taipei City 23148, TaiwanDepartment of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, 362 Chung-Cheng Road, Hsin-Tien District, New Taipei City 23148, TaiwanDivision of Internal Medicine, Chang-Gang Memorial Hospital, Taoyuan, No. 5 Fusing Street, Gueishan, Taoyuan County 333, TaiwanDepartment of Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 161 Section 6 Minquan East Road, Neihu District, Taipei City 114, TaiwanSchool of Pharmacy, National Defense Medical Center, No. 161 Section 6 Minquan East Road, Neihu District, Taipei City 114, TaiwanDepartment of Internal Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, 362 Chung-Cheng Road, Hsin-Tien District, New Taipei City 23148, TaiwanAim. The galactose single-point (GSP) test assesses functioning liver mass by measuring the galactose concentration in the blood 1 hour after its administration. The purpose of this study was to investigate the impact of hemodialysis (HD) on short-term and long-term liver function by use of GSP test. Methods. Seventy-four patients on maintenance HD (46 males and 28 females, 60.38 ± 11.86 years) with a mean time on HD of 60.77 ± 48.31 months were studied. The GSP values were compared in two groups: (1) before and after single session HD, and (2) after one year of maintenance HD. Results. Among the 74 HD patient, only the post-HD Cr levels and years on dialysis were significantly correlated with GSP values (r=0.280, P<0.05 and r=-0.240, P<0.05, resp.). 14 of 74 patients were selected for GSP evaluation before and after a single HD session, and the hepatic clearance of galactose was similar (pre-HD 410 ± 254 g/mL, post-HD 439 ± 298 g/mL, P=0.49). GSP values decreased from 420.20 ± 175.26 g/mL to 383.40 ± 153.97 g/mL after 1 year maintenance HD in other 15 patients (mean difference: 19.00 ± 37.66 g/mL, P<0.05). Conclusions. Patients on maintenance HD for several years may experience improvement of their liver function. However, a single HD session does not affect liver function significantly as assessed by the GSP test. Since the metabolism of galactose is dependent on liver blood flow and hepatic functional mass, further studies are needed.http://dx.doi.org/10.1155/2014/260939 |
| spellingShingle | Yi-Chou Hou Wen-Chih Liu Min-Tser Liao Kuo-Cheng Lu Lan Lo Heng-Chih Pan Chia-Chao Wu Oliver Yoa-Pu Hu Hung-Shang Tang Long-Term and Short-Term Effects of Hemodialysis on Liver Function Evaluated Using the Galactose Single-Point Test The Scientific World Journal |
| title | Long-Term and Short-Term Effects of Hemodialysis on Liver Function Evaluated Using the Galactose Single-Point Test |
| title_full | Long-Term and Short-Term Effects of Hemodialysis on Liver Function Evaluated Using the Galactose Single-Point Test |
| title_fullStr | Long-Term and Short-Term Effects of Hemodialysis on Liver Function Evaluated Using the Galactose Single-Point Test |
| title_full_unstemmed | Long-Term and Short-Term Effects of Hemodialysis on Liver Function Evaluated Using the Galactose Single-Point Test |
| title_short | Long-Term and Short-Term Effects of Hemodialysis on Liver Function Evaluated Using the Galactose Single-Point Test |
| title_sort | long term and short term effects of hemodialysis on liver function evaluated using the galactose single point test |
| url | http://dx.doi.org/10.1155/2014/260939 |
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