Innate and Adaptive Immunity in Calcific Aortic Valve Disease
Calcific aortic valve disease (CAVD) is the most common heart valve disorder. CAVD is a chronic process characterized by a pathologic mineralization of valve leaflets. Ectopic mineralization of the aortic valve involves complex relationships with immunity. Studies have highlighted that both innate a...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/851945 |
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| author | Patrick Mathieu Rihab Bouchareb Marie-Chloé Boulanger |
| author_facet | Patrick Mathieu Rihab Bouchareb Marie-Chloé Boulanger |
| author_sort | Patrick Mathieu |
| collection | DOAJ |
| description | Calcific aortic valve disease (CAVD) is the most common heart valve disorder. CAVD is a chronic process characterized by a pathologic mineralization of valve leaflets. Ectopic mineralization of the aortic valve involves complex relationships with immunity. Studies have highlighted that both innate and adaptive immunity play a role in the development of CAVD. In this regard, accumulating evidence indicates that fibrocalcific remodelling of the aortic valve is associated with activation of the NF-κB pathway. The expression of TNF-α and IL-6 is increased in human mineralized aortic valves and promotes an osteogenic program as well as the mineralization of valve interstitial cells (VICs), the main cellular component of the aortic valve. Different factors, including oxidized lipid species, activate the innate immune response through the Toll-like receptors. Moreover, VICs express 5-lipoxygenase and therefore produce leukotrienes, which may amplify the inflammatory response in the aortic valve. More recently, studies have emphasized that an adaptive immune response is triggered during CAVD. Herein, we are reviewing the link between the immune response and the development of CAVD and we have tried, whenever possible, to keep a translational approach. |
| format | Article |
| id | doaj-art-d39e2071c5604e39b7f3935322427fbd |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-d39e2071c5604e39b7f3935322427fbd2025-02-03T06:01:45ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/851945851945Innate and Adaptive Immunity in Calcific Aortic Valve DiseasePatrick Mathieu0Rihab Bouchareb1Marie-Chloé Boulanger2Laboratoire d’Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, QC, CanadaLaboratoire d’Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, QC, CanadaLaboratoire d’Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, QC, CanadaCalcific aortic valve disease (CAVD) is the most common heart valve disorder. CAVD is a chronic process characterized by a pathologic mineralization of valve leaflets. Ectopic mineralization of the aortic valve involves complex relationships with immunity. Studies have highlighted that both innate and adaptive immunity play a role in the development of CAVD. In this regard, accumulating evidence indicates that fibrocalcific remodelling of the aortic valve is associated with activation of the NF-κB pathway. The expression of TNF-α and IL-6 is increased in human mineralized aortic valves and promotes an osteogenic program as well as the mineralization of valve interstitial cells (VICs), the main cellular component of the aortic valve. Different factors, including oxidized lipid species, activate the innate immune response through the Toll-like receptors. Moreover, VICs express 5-lipoxygenase and therefore produce leukotrienes, which may amplify the inflammatory response in the aortic valve. More recently, studies have emphasized that an adaptive immune response is triggered during CAVD. Herein, we are reviewing the link between the immune response and the development of CAVD and we have tried, whenever possible, to keep a translational approach.http://dx.doi.org/10.1155/2015/851945 |
| spellingShingle | Patrick Mathieu Rihab Bouchareb Marie-Chloé Boulanger Innate and Adaptive Immunity in Calcific Aortic Valve Disease Journal of Immunology Research |
| title | Innate and Adaptive Immunity in Calcific Aortic Valve Disease |
| title_full | Innate and Adaptive Immunity in Calcific Aortic Valve Disease |
| title_fullStr | Innate and Adaptive Immunity in Calcific Aortic Valve Disease |
| title_full_unstemmed | Innate and Adaptive Immunity in Calcific Aortic Valve Disease |
| title_short | Innate and Adaptive Immunity in Calcific Aortic Valve Disease |
| title_sort | innate and adaptive immunity in calcific aortic valve disease |
| url | http://dx.doi.org/10.1155/2015/851945 |
| work_keys_str_mv | AT patrickmathieu innateandadaptiveimmunityincalcificaorticvalvedisease AT rihabbouchareb innateandadaptiveimmunityincalcificaorticvalvedisease AT mariechloeboulanger innateandadaptiveimmunityincalcificaorticvalvedisease |