The Use of Coupled Plasma Filtration Adsorption in Traumatic Rhabdomyolysis
Severe musculoskeletal injuries induce the release of sarcoplasmic elements such as muscle enzymes, potassium, and myoglobin in the systemic circulation. The circulating myoglobin damages the glomerulus and renal tubules. Conventional haemodialysis is not able to remove myoglobin, due to its high mo...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2017/5764961 |
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| author | Mario Pezzi Silvia Renda Anna Maria Giglio Anna Maria Scozzafava Simona Paola Tiburzi Patrizia Casella Fabrizio Iannelli Mario Verre |
| author_facet | Mario Pezzi Silvia Renda Anna Maria Giglio Anna Maria Scozzafava Simona Paola Tiburzi Patrizia Casella Fabrizio Iannelli Mario Verre |
| author_sort | Mario Pezzi |
| collection | DOAJ |
| description | Severe musculoskeletal injuries induce the release of sarcoplasmic elements such as muscle enzymes, potassium, and myoglobin in the systemic circulation. The circulating myoglobin damages the glomerulus and renal tubules. Conventional haemodialysis is not able to remove myoglobin, due to its high molecular weight (17,8 kilodaltons [kDa]). We treated four traumatic rhabdomyolysis patients with Coupled Plasma Filtration Adsorption (CPFA) in order to remove myoglobin followed by 14 hours of Continuous Veno-Venous Hemofiltration (CVVH). During the treatment, all patients showed clinical improvement with a decrease in muscular (creatine kinase [CK] and myoglobin) and renal (creatinine and potassium) damage indices. One patient, in spite of full renal recovery, died of cerebral haemorrhage on the 26th day of hospital stay. |
| format | Article |
| id | doaj-art-d38911154a13447e9fd32f92cdfa67fa |
| institution | Kabale University |
| issn | 2090-6420 2090-6439 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj-art-d38911154a13447e9fd32f92cdfa67fa2025-02-03T05:43:44ZengWileyCase Reports in Critical Care2090-64202090-64392017-01-01201710.1155/2017/57649615764961The Use of Coupled Plasma Filtration Adsorption in Traumatic RhabdomyolysisMario Pezzi0Silvia Renda1Anna Maria Giglio2Anna Maria Scozzafava3Simona Paola Tiburzi4Patrizia Casella5Fabrizio Iannelli6Mario Verre7Anaesthesia and Intensive Care Unit, General Hospital “Pugliese-Ciaccio”, Viale Pio X, 88100 Catanzaro, ItalyAnaesthesia and Intensive Care Unit, General Hospital “Pugliese-Ciaccio”, Viale Pio X, 88100 Catanzaro, ItalyAnaesthesia and Intensive Care Unit, General Hospital “Pugliese-Ciaccio”, Viale Pio X, 88100 Catanzaro, ItalyAnaesthesia and Intensive Care Unit, General Hospital “Pugliese-Ciaccio”, Viale Pio X, 88100 Catanzaro, ItalyAnaesthesia and Intensive Care Unit, General Hospital “Pugliese-Ciaccio”, Viale Pio X, 88100 Catanzaro, ItalyAnaesthesia and Intensive Care Unit, General Hospital “Pugliese-Ciaccio”, Viale Pio X, 88100 Catanzaro, ItalyBellco, 41037 Mirandola, ItalyAnaesthesia and Intensive Care Unit, General Hospital “Pugliese-Ciaccio”, Viale Pio X, 88100 Catanzaro, ItalySevere musculoskeletal injuries induce the release of sarcoplasmic elements such as muscle enzymes, potassium, and myoglobin in the systemic circulation. The circulating myoglobin damages the glomerulus and renal tubules. Conventional haemodialysis is not able to remove myoglobin, due to its high molecular weight (17,8 kilodaltons [kDa]). We treated four traumatic rhabdomyolysis patients with Coupled Plasma Filtration Adsorption (CPFA) in order to remove myoglobin followed by 14 hours of Continuous Veno-Venous Hemofiltration (CVVH). During the treatment, all patients showed clinical improvement with a decrease in muscular (creatine kinase [CK] and myoglobin) and renal (creatinine and potassium) damage indices. One patient, in spite of full renal recovery, died of cerebral haemorrhage on the 26th day of hospital stay.http://dx.doi.org/10.1155/2017/5764961 |
| spellingShingle | Mario Pezzi Silvia Renda Anna Maria Giglio Anna Maria Scozzafava Simona Paola Tiburzi Patrizia Casella Fabrizio Iannelli Mario Verre The Use of Coupled Plasma Filtration Adsorption in Traumatic Rhabdomyolysis Case Reports in Critical Care |
| title | The Use of Coupled Plasma Filtration Adsorption in Traumatic Rhabdomyolysis |
| title_full | The Use of Coupled Plasma Filtration Adsorption in Traumatic Rhabdomyolysis |
| title_fullStr | The Use of Coupled Plasma Filtration Adsorption in Traumatic Rhabdomyolysis |
| title_full_unstemmed | The Use of Coupled Plasma Filtration Adsorption in Traumatic Rhabdomyolysis |
| title_short | The Use of Coupled Plasma Filtration Adsorption in Traumatic Rhabdomyolysis |
| title_sort | use of coupled plasma filtration adsorption in traumatic rhabdomyolysis |
| url | http://dx.doi.org/10.1155/2017/5764961 |
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