Enhancement of ketoconazole dissolution rate by the liquisolid technique

Enhancement of ketoconazole dissolution rate by the liquisolid technique

The study was conducted to enhance the dissolution rate of ketoconazole (KCZ) (a poorly water-soluble drug) using the liquisolid technique. Microcrystalline cellulose, colloidal silica, PEG400 and polyvinyl pyrrolidone (PVP) were employed as a carrier, coating substance, nonvolatile solvent and addi...

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Bibliographic Details
Main Authors: Molaei Mir-Ali, Osouli-Bostanabad Karim, Adibkia Khosro, Shokri Javad, Asnaashari Solmaz, Javadzadeh Yousef
Format: Article
Language:English
Published: Sciendo 2018-09-01
Series:Acta Pharmaceutica
Subjects:
ketoconazole
liquisolid
dissolution rate
avicel
polymorphic changes
Online Access:https://doi.org/10.2478/acph-2018-0025
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