Synthesis of New DltA Inhibitors and Their Application as Adjuvant Antibiotics to Re-Sensitize Methicillin-Resistant <i>Staphylococcus aureus</i>

Synthesis of New DltA Inhibitors and Their Application as Adjuvant Antibiotics to Re-Sensitize Methicillin-Resistant <i>Staphylococcus aureus</i>

The synthesis of a new acyclic and cyclic series of D-Ala-AMP analogues was reported. Chemical modifications were introduced on the carbohydrate, the sulfamate linker, and/or the amino-acid <i>N</i>-terminal moiety in order to increase <i>in vivo</i> stability and cell permea...

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Main Authors: David Leparfait, Alexandre Mahé, Xiao Feng, Delphine Coupri, Fabien Le Cavelier, Nicolas Verneuil, Emmanuel Pfund, Aurélie Budin-Verneuil, Thierry Lequeux
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Molecules
Subjects:
nucleoside analogs
DltA inhibitor
antibiotic resistance
Online Access:https://www.mdpi.com/1420-3049/30/12/2569
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