Urinary Eosinophil Protein X in Childhood Asthma: Relation with Changes in Disease Control and Eosinophilic Airway Inflammation
The aim of this study was to assess cross-sectional and longitudinal correlations between uEPX and other markers of asthma control and eosinophilic airway inflammation. Methods. We measured uEPX at baseline, after 1 year and after 2 years in 205 atopic asthmatic children using inhaled fluticasone. A...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/532619 |
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| author | Marianne Nuijsink Wim C. J. Hop Peter J. Sterk Eric J. Duiverman Johan C. De Jongste |
| author_facet | Marianne Nuijsink Wim C. J. Hop Peter J. Sterk Eric J. Duiverman Johan C. De Jongste |
| author_sort | Marianne Nuijsink |
| collection | DOAJ |
| description | The aim of this study was to assess cross-sectional and longitudinal correlations between uEPX and other markers of asthma control and eosinophilic airway inflammation. Methods. We measured uEPX at baseline, after 1 year and after 2 years in 205 atopic asthmatic children using inhaled fluticasone. At the same time points, we assessed symptom scores (2 weeks diary card), lung function (forced expiratory volume in one second (FEV1)), airway hyperresponsiveness (AHR), and percentage eosinophils in induced sputum (% eos). Results. We found negative correlations between uEPX and FEV1 at baseline (r=-0.18,P=0.01), after 1 year (r=-0.25,P<0.01) and after 2 years (r=-0.21,P=0.02). Within-patient changes of uEPX showed a negative association with FEV1 changes (at 1 year: r=-0.24,P=0.01
; at 2 years: r=-0.21,P=0.03). Within-patient changes from baseline of uEPX correlated with changes in % eos. No relations were found between uEPX and symptoms. Conclusion. In this population of children with atopic asthma, uEPX correlated with FEV1 and % eos, and within-subjects changes in uEPX correlated with changes in FEV1 and % eos. As the associations were weak and the scatter of uEPX wide, it seems unlikely that uEPX will be useful as a biomarker for monitoring asthma control in the individual child. |
| format | Article |
| id | doaj-art-d37936c0a621474eab83bae9b71f3b2b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d37936c0a621474eab83bae9b71f3b2b2025-02-03T01:31:37ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/532619532619Urinary Eosinophil Protein X in Childhood Asthma: Relation with Changes in Disease Control and Eosinophilic Airway InflammationMarianne Nuijsink0Wim C. J. Hop1Peter J. Sterk2Eric J. Duiverman3Johan C. De Jongste4Department of Pediatric Respiratory Medicine, Juliana Children’s Hospital, HAGA Teaching Hospital, P.O. Box 60605, 2506 LP, The Hague, The NetherlandsDepartment of Biostatistics, Erasmus University Medical Centre, P.O. Box 2040, 3000 CA, Rotterdam, The NetherlandsDepartment of Respiratory Medicine, Academic Medical University of Amsterdam, P.O. Box 22660, 1100 DD, Amsterdam, The NetherlandsDepartment of Pediatric Respiratory Medicine, Beatrix Children's Hospital, University Medical Centre Groningen, P.O. Box 30001, 9700 RB, Groningen, The NetherlandsDepartment of Pediatric Respiratory Medicine, Sophia Children's Hospital, Erasmus University Medical Centre, P.O. Box 2060, 3000 CB, Rotterdam, The NetherlandsThe aim of this study was to assess cross-sectional and longitudinal correlations between uEPX and other markers of asthma control and eosinophilic airway inflammation. Methods. We measured uEPX at baseline, after 1 year and after 2 years in 205 atopic asthmatic children using inhaled fluticasone. At the same time points, we assessed symptom scores (2 weeks diary card), lung function (forced expiratory volume in one second (FEV1)), airway hyperresponsiveness (AHR), and percentage eosinophils in induced sputum (% eos). Results. We found negative correlations between uEPX and FEV1 at baseline (r=-0.18,P=0.01), after 1 year (r=-0.25,P<0.01) and after 2 years (r=-0.21,P=0.02). Within-patient changes of uEPX showed a negative association with FEV1 changes (at 1 year: r=-0.24,P=0.01 ; at 2 years: r=-0.21,P=0.03). Within-patient changes from baseline of uEPX correlated with changes in % eos. No relations were found between uEPX and symptoms. Conclusion. In this population of children with atopic asthma, uEPX correlated with FEV1 and % eos, and within-subjects changes in uEPX correlated with changes in FEV1 and % eos. As the associations were weak and the scatter of uEPX wide, it seems unlikely that uEPX will be useful as a biomarker for monitoring asthma control in the individual child.http://dx.doi.org/10.1155/2013/532619 |
| spellingShingle | Marianne Nuijsink Wim C. J. Hop Peter J. Sterk Eric J. Duiverman Johan C. De Jongste Urinary Eosinophil Protein X in Childhood Asthma: Relation with Changes in Disease Control and Eosinophilic Airway Inflammation Mediators of Inflammation |
| title | Urinary Eosinophil Protein X in Childhood Asthma: Relation with Changes in Disease Control and Eosinophilic Airway Inflammation |
| title_full | Urinary Eosinophil Protein X in Childhood Asthma: Relation with Changes in Disease Control and Eosinophilic Airway Inflammation |
| title_fullStr | Urinary Eosinophil Protein X in Childhood Asthma: Relation with Changes in Disease Control and Eosinophilic Airway Inflammation |
| title_full_unstemmed | Urinary Eosinophil Protein X in Childhood Asthma: Relation with Changes in Disease Control and Eosinophilic Airway Inflammation |
| title_short | Urinary Eosinophil Protein X in Childhood Asthma: Relation with Changes in Disease Control and Eosinophilic Airway Inflammation |
| title_sort | urinary eosinophil protein x in childhood asthma relation with changes in disease control and eosinophilic airway inflammation |
| url | http://dx.doi.org/10.1155/2013/532619 |
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