Novel type II toxin-antitoxin systems with VapD-like proteins

Novel type II toxin-antitoxin systems with VapD-like proteins

ABSTRACT Type II toxin-antitoxin (TA) systems are widespread in prokaryotes. They consist of neighboring genes encoding two small proteins: a toxin that inhibits a critical cellular process and an antitoxin that binds to and neutralizes the toxin. The VapD nuclease and the VapX antitoxin comprise a...

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Bibliographic Details
Main Authors: Konstantin Gilep, Dmitry Bikmetov, Aleksandr Popov, Anastasiia Rusanova, Shunsuke Tagami, Svetlana Dubiley, Konstantin Severinov
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:mBio
Subjects:
toxin-antitoxin systems
VapD
SOS-response
Cas2
evolution
Online Access:https://journals.asm.org/doi/10.1128/mbio.00003-25
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