pH-responsive nanovesicles capable of remodeling the tumor microenvironment enable activatable near-infrared-II fluorescence image-guided enhanced radiotherapy
Traditional radiotherapy (RT) lacks the precision to distinguish between tumor and normal tissues, leading to inevitable X-ray-induced side effects in patients. Therefore, it is crucial to develop integrated imaging and therapeutic modalities that can reduce side effects on surrounding healthy tissu...
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Elsevier
2025-06-01
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| author | Lin Zhao Mengzhen Wang Yang Sun Jinpeng Xu Qinrui Fu Wenjing Xiao |
| author_facet | Lin Zhao Mengzhen Wang Yang Sun Jinpeng Xu Qinrui Fu Wenjing Xiao |
| author_sort | Lin Zhao |
| collection | DOAJ |
| description | Traditional radiotherapy (RT) lacks the precision to distinguish between tumor and normal tissues, leading to inevitable X-ray-induced side effects in patients. Therefore, it is crucial to develop integrated imaging and therapeutic modalities that can reduce side effects on surrounding healthy tissues while enhancing susceptibility to tumor tissues. In this study, we developed a pH-responsive nanodrug (AuNRs-Mn3O4-Ag2S Ve) by self-assembling the second near-infrared (NIR-II, 950–1700 nm) fluorescent probe Ag2S quantum dots (QDs), multifunctional nanozyme Mn3O4 nanoparticles (NPs), and radiosensitizer gold nanorods (AuNRs) into a single nanoplatform via an emulsion process. This nanodrug enables precise tumor localization for accurately guided RT and multi-angle sensitization of RT. Upon intravenous administration, the nanodrug disintegrates in the tumor area due to the pH-sensitive polymer P4VP, releasing Ag2S QDs which are specifically activated by the acidic environment, thereby “turning on” the NIR-II fluorescence signal. The optimal timing of the NIR-II fluorescence signal within the tumor region after intravenous injection was investigated, providing a reference for guided RT. In vitro and in vivo experiments confirmed the efficient enhancement of tumor radiosensitization by AuNRs and Mn3O4 NPs. The specific imaging modality that transitions the fluorescence signal from “off” to “on” has been successfully implemented, addressing the limitations of conventional RT and enhancing radiosensitivity. The integration of imaging and therapeutic approaches in this study presents a promising modality for image-guided tumor RT. |
| format | Article |
| id | doaj-art-d36ffe3d42c049ffa4e80a35fa2f6d9a |
| institution | OA Journals |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
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| series | Materials Today Bio |
| spelling | doaj-art-d36ffe3d42c049ffa4e80a35fa2f6d9a2025-08-20T02:11:26ZengElsevierMaterials Today Bio2590-00642025-06-013210172510.1016/j.mtbio.2025.101725pH-responsive nanovesicles capable of remodeling the tumor microenvironment enable activatable near-infrared-II fluorescence image-guided enhanced radiotherapyLin Zhao0Mengzhen Wang1Yang Sun2Jinpeng Xu3Qinrui Fu4Wenjing Xiao5Department of Radiotherapy, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266021, China; Institute of Chronic Disease, College of Medicine, Qingdao University, Qingdao, 266021, ChinaInstitute of Chronic Disease, College of Medicine, Qingdao University, Qingdao, 266021, ChinaDepartment of Radiotherapy, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266021, ChinaDepartment of Radiotherapy, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266021, ChinaInstitute of Chronic Disease, College of Medicine, Qingdao University, Qingdao, 266021, China; Corresponding author.Department of Radiotherapy, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266021, China; Corresponding author.Traditional radiotherapy (RT) lacks the precision to distinguish between tumor and normal tissues, leading to inevitable X-ray-induced side effects in patients. Therefore, it is crucial to develop integrated imaging and therapeutic modalities that can reduce side effects on surrounding healthy tissues while enhancing susceptibility to tumor tissues. In this study, we developed a pH-responsive nanodrug (AuNRs-Mn3O4-Ag2S Ve) by self-assembling the second near-infrared (NIR-II, 950–1700 nm) fluorescent probe Ag2S quantum dots (QDs), multifunctional nanozyme Mn3O4 nanoparticles (NPs), and radiosensitizer gold nanorods (AuNRs) into a single nanoplatform via an emulsion process. This nanodrug enables precise tumor localization for accurately guided RT and multi-angle sensitization of RT. Upon intravenous administration, the nanodrug disintegrates in the tumor area due to the pH-sensitive polymer P4VP, releasing Ag2S QDs which are specifically activated by the acidic environment, thereby “turning on” the NIR-II fluorescence signal. The optimal timing of the NIR-II fluorescence signal within the tumor region after intravenous injection was investigated, providing a reference for guided RT. In vitro and in vivo experiments confirmed the efficient enhancement of tumor radiosensitization by AuNRs and Mn3O4 NPs. The specific imaging modality that transitions the fluorescence signal from “off” to “on” has been successfully implemented, addressing the limitations of conventional RT and enhancing radiosensitivity. The integration of imaging and therapeutic approaches in this study presents a promising modality for image-guided tumor RT.http://www.sciencedirect.com/science/article/pii/S2590006425002844RadiotherapyNanodrugpH responsiveNear-infrared-II fluorescence imagingRadiosensitizationCancer |
| spellingShingle | Lin Zhao Mengzhen Wang Yang Sun Jinpeng Xu Qinrui Fu Wenjing Xiao pH-responsive nanovesicles capable of remodeling the tumor microenvironment enable activatable near-infrared-II fluorescence image-guided enhanced radiotherapy Materials Today Bio Radiotherapy Nanodrug pH responsive Near-infrared-II fluorescence imaging Radiosensitization Cancer |
| title | pH-responsive nanovesicles capable of remodeling the tumor microenvironment enable activatable near-infrared-II fluorescence image-guided enhanced radiotherapy |
| title_full | pH-responsive nanovesicles capable of remodeling the tumor microenvironment enable activatable near-infrared-II fluorescence image-guided enhanced radiotherapy |
| title_fullStr | pH-responsive nanovesicles capable of remodeling the tumor microenvironment enable activatable near-infrared-II fluorescence image-guided enhanced radiotherapy |
| title_full_unstemmed | pH-responsive nanovesicles capable of remodeling the tumor microenvironment enable activatable near-infrared-II fluorescence image-guided enhanced radiotherapy |
| title_short | pH-responsive nanovesicles capable of remodeling the tumor microenvironment enable activatable near-infrared-II fluorescence image-guided enhanced radiotherapy |
| title_sort | ph responsive nanovesicles capable of remodeling the tumor microenvironment enable activatable near infrared ii fluorescence image guided enhanced radiotherapy |
| topic | Radiotherapy Nanodrug pH responsive Near-infrared-II fluorescence imaging Radiosensitization Cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425002844 |
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