The Role of Acute Phase Reactants, Including α1-Acid Glycoprotein, in Predicting Onset and Severity of Retinopathy of Prematurity
<b>Background</b>: Retinopathy of prematurity (ROP) is a serious disease causing blindness in childhood. Gestational age (GA) and birth weight are major factors associated with the development and progression of ROP, but postnatal systemic inflammation is also an important well-known ris...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-02-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/15/5/571 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850225266359533568 |
|---|---|
| author | Yoko Nakazawa Tsutomu Yasukawa Haruo Goto Satoru Kobayashi Kyoko Yokoi |
| author_facet | Yoko Nakazawa Tsutomu Yasukawa Haruo Goto Satoru Kobayashi Kyoko Yokoi |
| author_sort | Yoko Nakazawa |
| collection | DOAJ |
| description | <b>Background</b>: Retinopathy of prematurity (ROP) is a serious disease causing blindness in childhood. Gestational age (GA) and birth weight are major factors associated with the development and progression of ROP, but postnatal systemic inflammation is also an important well-known risk factor. <b>Methods</b>: This study retrospectively analyzed the relationship between systemic inflammation and ROP severity using the corrected GA (CGA), which reflects the intrinsic immaturity of the infant, rather than days of life. Three acute phase reactants (APRs) were analyzed using discriminant probability and compared with conventional ROP prediction models: C-reactive protein, α1AG, and haptoglobin. <b>Results</b>: Alpha 1AG was the best predictor of ROP onset and progression, and could be predicted with blood samples up to 30 weeks (30 W) CGA (<i>p</i> = 0.006). Incorporation of APR into the conventional GA + body weight (BW), ROP score, and Children’s Hospital of Philadelphia (CHOP) predictive models improved the decision to treat (4–5% increase in discrimination probability) and helped determine whether treatment of ROP was necessary by CGA 30 W. <b>Conclusions</b>: Therefore, simply adding α1AG protein to the assessment is useful for predicting the need to treat ROP. |
| format | Article |
| id | doaj-art-d3698a8bb0f846bcbcea7debe77ae4e2 |
| institution | OA Journals |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-d3698a8bb0f846bcbcea7debe77ae4e22025-08-20T02:05:24ZengMDPI AGDiagnostics2075-44182025-02-0115557110.3390/diagnostics15050571The Role of Acute Phase Reactants, Including α1-Acid Glycoprotein, in Predicting Onset and Severity of Retinopathy of PrematurityYoko Nakazawa0Tsutomu Yasukawa1Haruo Goto2Satoru Kobayashi3Kyoko Yokoi4Department of Ophthalmology, Nagoya City University West Medical Center, Nagoya 462-8505, JapanDepartment of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, JapanDepartment of Pediatrics, Nagoya City University West Medical Center, Nagoya 462-8505, JapanDepartment of Pediatrics, Nagoya City University West Medical Center, Nagoya 462-8505, JapanDepartment of Pediatrics, Nagoya City University West Medical Center, Nagoya 462-8505, Japan<b>Background</b>: Retinopathy of prematurity (ROP) is a serious disease causing blindness in childhood. Gestational age (GA) and birth weight are major factors associated with the development and progression of ROP, but postnatal systemic inflammation is also an important well-known risk factor. <b>Methods</b>: This study retrospectively analyzed the relationship between systemic inflammation and ROP severity using the corrected GA (CGA), which reflects the intrinsic immaturity of the infant, rather than days of life. Three acute phase reactants (APRs) were analyzed using discriminant probability and compared with conventional ROP prediction models: C-reactive protein, α1AG, and haptoglobin. <b>Results</b>: Alpha 1AG was the best predictor of ROP onset and progression, and could be predicted with blood samples up to 30 weeks (30 W) CGA (<i>p</i> = 0.006). Incorporation of APR into the conventional GA + body weight (BW), ROP score, and Children’s Hospital of Philadelphia (CHOP) predictive models improved the decision to treat (4–5% increase in discrimination probability) and helped determine whether treatment of ROP was necessary by CGA 30 W. <b>Conclusions</b>: Therefore, simply adding α1AG protein to the assessment is useful for predicting the need to treat ROP.https://www.mdpi.com/2075-4418/15/5/571retinopathy of prematurityacute phase reactantspredictive factordiscriminant probabilityC-reactive proteinalfa 1 acid glycoprotein |
| spellingShingle | Yoko Nakazawa Tsutomu Yasukawa Haruo Goto Satoru Kobayashi Kyoko Yokoi The Role of Acute Phase Reactants, Including α1-Acid Glycoprotein, in Predicting Onset and Severity of Retinopathy of Prematurity Diagnostics retinopathy of prematurity acute phase reactants predictive factor discriminant probability C-reactive protein alfa 1 acid glycoprotein |
| title | The Role of Acute Phase Reactants, Including α1-Acid Glycoprotein, in Predicting Onset and Severity of Retinopathy of Prematurity |
| title_full | The Role of Acute Phase Reactants, Including α1-Acid Glycoprotein, in Predicting Onset and Severity of Retinopathy of Prematurity |
| title_fullStr | The Role of Acute Phase Reactants, Including α1-Acid Glycoprotein, in Predicting Onset and Severity of Retinopathy of Prematurity |
| title_full_unstemmed | The Role of Acute Phase Reactants, Including α1-Acid Glycoprotein, in Predicting Onset and Severity of Retinopathy of Prematurity |
| title_short | The Role of Acute Phase Reactants, Including α1-Acid Glycoprotein, in Predicting Onset and Severity of Retinopathy of Prematurity |
| title_sort | role of acute phase reactants including α1 acid glycoprotein in predicting onset and severity of retinopathy of prematurity |
| topic | retinopathy of prematurity acute phase reactants predictive factor discriminant probability C-reactive protein alfa 1 acid glycoprotein |
| url | https://www.mdpi.com/2075-4418/15/5/571 |
| work_keys_str_mv | AT yokonakazawa theroleofacutephasereactantsincludinga1acidglycoproteininpredictingonsetandseverityofretinopathyofprematurity AT tsutomuyasukawa theroleofacutephasereactantsincludinga1acidglycoproteininpredictingonsetandseverityofretinopathyofprematurity AT haruogoto theroleofacutephasereactantsincludinga1acidglycoproteininpredictingonsetandseverityofretinopathyofprematurity AT satorukobayashi theroleofacutephasereactantsincludinga1acidglycoproteininpredictingonsetandseverityofretinopathyofprematurity AT kyokoyokoi theroleofacutephasereactantsincludinga1acidglycoproteininpredictingonsetandseverityofretinopathyofprematurity AT yokonakazawa roleofacutephasereactantsincludinga1acidglycoproteininpredictingonsetandseverityofretinopathyofprematurity AT tsutomuyasukawa roleofacutephasereactantsincludinga1acidglycoproteininpredictingonsetandseverityofretinopathyofprematurity AT haruogoto roleofacutephasereactantsincludinga1acidglycoproteininpredictingonsetandseverityofretinopathyofprematurity AT satorukobayashi roleofacutephasereactantsincludinga1acidglycoproteininpredictingonsetandseverityofretinopathyofprematurity AT kyokoyokoi roleofacutephasereactantsincludinga1acidglycoproteininpredictingonsetandseverityofretinopathyofprematurity |