Squalamine and claramine A1 disperse Pseudomonas aeruginosa biofilm
Pseudomonas aeruginosa is an opportunistic pathogen that causes both acute and chronic infections, including pneumonia, bloodstream infections, urinary tract infections, and surgical site infections. It poses a significant threat to individuals with chronic lung conditions, particularly those with c...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Biofilm |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590207525000413 |
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| author | Anne-Sophie Tareau Ali Tahrioui Mathieu Gonzalez Evan Croize Jennifer Varin Simon Magalie Barreau Audrey David Fany Reffuveille Jean-Michel Brunel Olivier Lesouhaitier Sylvie Chevalier |
| author_facet | Anne-Sophie Tareau Ali Tahrioui Mathieu Gonzalez Evan Croize Jennifer Varin Simon Magalie Barreau Audrey David Fany Reffuveille Jean-Michel Brunel Olivier Lesouhaitier Sylvie Chevalier |
| author_sort | Anne-Sophie Tareau |
| collection | DOAJ |
| description | Pseudomonas aeruginosa is an opportunistic pathogen that causes both acute and chronic infections, including pneumonia, bloodstream infections, urinary tract infections, and surgical site infections. It poses a significant threat to individuals with chronic lung conditions, particularly those with cystic fibrosis. Squalamine and claramine A1 have emerged as promising antibacterial compounds, exhibiting activity against a broad range of both Gram-positive and Gram-negative bacteria. Beyond their potent antibacterial properties, our findings reveal that sub-inhibitory concentrations of claramine A1 and squalamine can disperse pre-formed P. aeruginosa biofilm without impacting bacterial growth. While claramine A1, but not squalamine, enhances membrane fluidity, the structural difference between these compounds lies primarily in their spermine and spermidine moieties. Notably, we found that spermine, unlike spermidine, was able to both disperse biofilm and increase membrane fluidity. Together, our results suggest that while both compounds are effective at disrupting P. aeruginosa biofilm, they likely act through distinct mechanisms. |
| format | Article |
| id | doaj-art-d355de6bbcbf4f5a914e603ada0c8a3a |
| institution | OA Journals |
| issn | 2590-2075 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biofilm |
| spelling | doaj-art-d355de6bbcbf4f5a914e603ada0c8a3a2025-08-20T02:17:14ZengElsevierBiofilm2590-20752025-06-01910029310.1016/j.bioflm.2025.100293Squalamine and claramine A1 disperse Pseudomonas aeruginosa biofilmAnne-Sophie Tareau0Ali Tahrioui1Mathieu Gonzalez2Evan Croize3Jennifer Varin Simon4Magalie Barreau5Audrey David6Fany Reffuveille7Jean-Michel Brunel8Olivier Lesouhaitier9Sylvie Chevalier10Univ Rouen Normandie, Université Caen Normandie, Normandie Univ, CBSA UR 4312, F-76000, Rouen, FranceUniv Rouen Normandie, Université Caen Normandie, Normandie Univ, CBSA UR 4312, F-76000, Rouen, France; Univ Rouen Normandie, Platform of Sanitary Safety, Evreux Campus, PS2E, FranceUniv Rouen Normandie, Université Caen Normandie, Normandie Univ, CBSA UR 4312, F-76000, Rouen, FranceUniv Rouen Normandie, Université Caen Normandie, Normandie Univ, CBSA UR 4312, F-76000, Rouen, FranceUniversité de Reims Champagne-Ardenne, BIOS, Reims, FranceUniv Rouen Normandie, Université Caen Normandie, Normandie Univ, CBSA UR 4312, F-76000, Rouen, France; Univ Rouen Normandie, Platform of Sanitary Safety, Evreux Campus, PS2E, FranceUniv Rouen Normandie, Université Caen Normandie, Normandie Univ, CBSA UR 4312, F-76000, Rouen, FranceUniversité de Reims Champagne-Ardenne, BIOS, Reims, FranceAix Marseille Univ, INSERM, SSA, MCT, F-13385, Marseille, FranceUniv Rouen Normandie, Université Caen Normandie, Normandie Univ, CBSA UR 4312, F-76000, Rouen, France; Univ Rouen Normandie, Platform of Sanitary Safety, Evreux Campus, PS2E, FranceUniv Rouen Normandie, Université Caen Normandie, Normandie Univ, CBSA UR 4312, F-76000, Rouen, France; Univ Rouen Normandie, Platform of Sanitary Safety, Evreux Campus, PS2E, France; Corresponding author. Unité de recherche Communication Bactérienne et Stratégies Anti-infectieuses, CBSA UR4312, 55 rue St Germain, Evreux, 27000, France.Pseudomonas aeruginosa is an opportunistic pathogen that causes both acute and chronic infections, including pneumonia, bloodstream infections, urinary tract infections, and surgical site infections. It poses a significant threat to individuals with chronic lung conditions, particularly those with cystic fibrosis. Squalamine and claramine A1 have emerged as promising antibacterial compounds, exhibiting activity against a broad range of both Gram-positive and Gram-negative bacteria. Beyond their potent antibacterial properties, our findings reveal that sub-inhibitory concentrations of claramine A1 and squalamine can disperse pre-formed P. aeruginosa biofilm without impacting bacterial growth. While claramine A1, but not squalamine, enhances membrane fluidity, the structural difference between these compounds lies primarily in their spermine and spermidine moieties. Notably, we found that spermine, unlike spermidine, was able to both disperse biofilm and increase membrane fluidity. Together, our results suggest that while both compounds are effective at disrupting P. aeruginosa biofilm, they likely act through distinct mechanisms.http://www.sciencedirect.com/science/article/pii/S2590207525000413Pseudomonas aeruginosaBiofilmEradicationSqualamineClaramine A1Spermine |
| spellingShingle | Anne-Sophie Tareau Ali Tahrioui Mathieu Gonzalez Evan Croize Jennifer Varin Simon Magalie Barreau Audrey David Fany Reffuveille Jean-Michel Brunel Olivier Lesouhaitier Sylvie Chevalier Squalamine and claramine A1 disperse Pseudomonas aeruginosa biofilm Biofilm Pseudomonas aeruginosa Biofilm Eradication Squalamine Claramine A1 Spermine |
| title | Squalamine and claramine A1 disperse Pseudomonas aeruginosa biofilm |
| title_full | Squalamine and claramine A1 disperse Pseudomonas aeruginosa biofilm |
| title_fullStr | Squalamine and claramine A1 disperse Pseudomonas aeruginosa biofilm |
| title_full_unstemmed | Squalamine and claramine A1 disperse Pseudomonas aeruginosa biofilm |
| title_short | Squalamine and claramine A1 disperse Pseudomonas aeruginosa biofilm |
| title_sort | squalamine and claramine a1 disperse pseudomonas aeruginosa biofilm |
| topic | Pseudomonas aeruginosa Biofilm Eradication Squalamine Claramine A1 Spermine |
| url | http://www.sciencedirect.com/science/article/pii/S2590207525000413 |
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