QT and QTc in Male Patients with Psychotic Disorders Treated with Atypical Neuroleptics
Objective. We explored the potential association between antipsychotics and QT/QTc duration changes in hospitalized male patients with psychotic disorders. Methods. The chart review was conducted on 184 male patients hospitalized between 2013 and 2015 at the Psychiatric Clinic of Pisa, Italy. Patien...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2017/1951628 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832568318502895616 |
|---|---|
| author | Mario Miniati Marly Simoncini Federica Vanelli Caterina Franceschini Gabriele Massimetti Claudia Carmassi Liliana Dell’Osso |
| author_facet | Mario Miniati Marly Simoncini Federica Vanelli Caterina Franceschini Gabriele Massimetti Claudia Carmassi Liliana Dell’Osso |
| author_sort | Mario Miniati |
| collection | DOAJ |
| description | Objective. We explored the potential association between antipsychotics and QT/QTc duration changes in hospitalized male patients with psychotic disorders. Methods. The chart review was conducted on 184 male patients hospitalized between 2013 and 2015 at the Psychiatric Clinic of Pisa, Italy. Patients who were treated with one atypical antipsychotic at the time of the ECG recording were 109/184 (59.2%). QT/QTc were compared considering the atypical antipsychotic received. Results. 96.3% (n = 105/109) of the sample showed QTc values ≤ 430 ms; 4 patients (3.7%) had QTc values between 430 and 450 msec (2 with paliperidone, 1 with risperidone, and 1 with olanzapine). The mean QT duration of the overall sample was 368.0 ± 28.0 and the mean QTc 400.1 ± 17.8. QTc values did not reveal statistically significant differences. QT values were significantly different (chi-square = 17.3; df = 5; p = .004). Statistically significant differences between aripiprazole and paliperidone (349.0 ± 28.3 versus 390.5 ± 29.8; p = .002) and between clozapine and paliperidone (361.1 ± 22.43 versus 390.5 ± 29.8; p = .033) were found. Conclusions. Aripiprazole was the least interfering neuroleptic with QT/QTc. Paliperidone was the atypical neuroleptic with the most relevant difference with aripiprazole, but only on QT. |
| format | Article |
| id | doaj-art-d34af911234640eba7df3fa5872aaaf6 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-d34af911234640eba7df3fa5872aaaf62025-02-03T00:59:17ZengWileyThe Scientific World Journal2356-61401537-744X2017-01-01201710.1155/2017/19516281951628QT and QTc in Male Patients with Psychotic Disorders Treated with Atypical NeurolepticsMario Miniati0Marly Simoncini1Federica Vanelli2Caterina Franceschini3Gabriele Massimetti4Claudia Carmassi5Liliana Dell’Osso6Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalySection of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalySection of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalySection of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalySection of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalySection of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalySection of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, ItalyObjective. We explored the potential association between antipsychotics and QT/QTc duration changes in hospitalized male patients with psychotic disorders. Methods. The chart review was conducted on 184 male patients hospitalized between 2013 and 2015 at the Psychiatric Clinic of Pisa, Italy. Patients who were treated with one atypical antipsychotic at the time of the ECG recording were 109/184 (59.2%). QT/QTc were compared considering the atypical antipsychotic received. Results. 96.3% (n = 105/109) of the sample showed QTc values ≤ 430 ms; 4 patients (3.7%) had QTc values between 430 and 450 msec (2 with paliperidone, 1 with risperidone, and 1 with olanzapine). The mean QT duration of the overall sample was 368.0 ± 28.0 and the mean QTc 400.1 ± 17.8. QTc values did not reveal statistically significant differences. QT values were significantly different (chi-square = 17.3; df = 5; p = .004). Statistically significant differences between aripiprazole and paliperidone (349.0 ± 28.3 versus 390.5 ± 29.8; p = .002) and between clozapine and paliperidone (361.1 ± 22.43 versus 390.5 ± 29.8; p = .033) were found. Conclusions. Aripiprazole was the least interfering neuroleptic with QT/QTc. Paliperidone was the atypical neuroleptic with the most relevant difference with aripiprazole, but only on QT.http://dx.doi.org/10.1155/2017/1951628 |
| spellingShingle | Mario Miniati Marly Simoncini Federica Vanelli Caterina Franceschini Gabriele Massimetti Claudia Carmassi Liliana Dell’Osso QT and QTc in Male Patients with Psychotic Disorders Treated with Atypical Neuroleptics The Scientific World Journal |
| title | QT and QTc in Male Patients with Psychotic Disorders Treated with Atypical Neuroleptics |
| title_full | QT and QTc in Male Patients with Psychotic Disorders Treated with Atypical Neuroleptics |
| title_fullStr | QT and QTc in Male Patients with Psychotic Disorders Treated with Atypical Neuroleptics |
| title_full_unstemmed | QT and QTc in Male Patients with Psychotic Disorders Treated with Atypical Neuroleptics |
| title_short | QT and QTc in Male Patients with Psychotic Disorders Treated with Atypical Neuroleptics |
| title_sort | qt and qtc in male patients with psychotic disorders treated with atypical neuroleptics |
| url | http://dx.doi.org/10.1155/2017/1951628 |
| work_keys_str_mv | AT mariominiati qtandqtcinmalepatientswithpsychoticdisorderstreatedwithatypicalneuroleptics AT marlysimoncini qtandqtcinmalepatientswithpsychoticdisorderstreatedwithatypicalneuroleptics AT federicavanelli qtandqtcinmalepatientswithpsychoticdisorderstreatedwithatypicalneuroleptics AT caterinafranceschini qtandqtcinmalepatientswithpsychoticdisorderstreatedwithatypicalneuroleptics AT gabrielemassimetti qtandqtcinmalepatientswithpsychoticdisorderstreatedwithatypicalneuroleptics AT claudiacarmassi qtandqtcinmalepatientswithpsychoticdisorderstreatedwithatypicalneuroleptics AT lilianadellosso qtandqtcinmalepatientswithpsychoticdisorderstreatedwithatypicalneuroleptics |