Pain and Frailty in Childhood Cancer Survivors: A Narrative Review
A significant proportion of childhood cancer survivors experience persistent health problems related to cancer or cancer treatment exposures, including accelerated or early onset of aging. Survivors are more likely than non-cancer peers to present a frail phenotype suggestive of reduced physiologic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/32/1/22 |
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| author | Chiara Papini Jaspreet K. Sodhi Cassie M. Argenbright Kirsten K. Ness Tara M. Brinkman |
| author_facet | Chiara Papini Jaspreet K. Sodhi Cassie M. Argenbright Kirsten K. Ness Tara M. Brinkman |
| author_sort | Chiara Papini |
| collection | DOAJ |
| description | A significant proportion of childhood cancer survivors experience persistent health problems related to cancer or cancer treatment exposures, including accelerated or early onset of aging. Survivors are more likely than non-cancer peers to present a frail phenotype suggestive of reduced physiologic reserve and have symptoms that interfere with function in daily life, including pain. Studies in the general population, mostly among older adults, suggest that pain is a significant contributor to development and progression of frail health. This association has not been explored among childhood cancer survivors. In this narrative review, we highlight this gap by summarizing the epidemiologic evidence on pain and frailty, including their prevalence, common risk factors, and correlates in childhood cancer survivors. We further discuss associations between pain and frailty in non-cancer populations, likely biological mechanisms in survivors, and potential interventions targeting both domains. |
| format | Article |
| id | doaj-art-d32b91c930b043ccb92759167befdee8 |
| institution | Kabale University |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-d32b91c930b043ccb92759167befdee82025-01-24T13:28:23ZengMDPI AGCurrent Oncology1198-00521718-77292024-12-013212210.3390/curroncol32010022Pain and Frailty in Childhood Cancer Survivors: A Narrative ReviewChiara Papini0Jaspreet K. Sodhi1Cassie M. Argenbright2Kirsten K. Ness3Tara M. Brinkman4Psychology and Biobehavioral Sciences, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USASchool of Physical Therapy, Marshall University, 2847 5th Ave, Huntington, WV 25702, USAPsychology and Biobehavioral Sciences, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USAEpidemiology and Cancer Control, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USAPsychology and Biobehavioral Sciences, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USAA significant proportion of childhood cancer survivors experience persistent health problems related to cancer or cancer treatment exposures, including accelerated or early onset of aging. Survivors are more likely than non-cancer peers to present a frail phenotype suggestive of reduced physiologic reserve and have symptoms that interfere with function in daily life, including pain. Studies in the general population, mostly among older adults, suggest that pain is a significant contributor to development and progression of frail health. This association has not been explored among childhood cancer survivors. In this narrative review, we highlight this gap by summarizing the epidemiologic evidence on pain and frailty, including their prevalence, common risk factors, and correlates in childhood cancer survivors. We further discuss associations between pain and frailty in non-cancer populations, likely biological mechanisms in survivors, and potential interventions targeting both domains.https://www.mdpi.com/1718-7729/32/1/22painfrailtychildhood cancer survivors |
| spellingShingle | Chiara Papini Jaspreet K. Sodhi Cassie M. Argenbright Kirsten K. Ness Tara M. Brinkman Pain and Frailty in Childhood Cancer Survivors: A Narrative Review Current Oncology pain frailty childhood cancer survivors |
| title | Pain and Frailty in Childhood Cancer Survivors: A Narrative Review |
| title_full | Pain and Frailty in Childhood Cancer Survivors: A Narrative Review |
| title_fullStr | Pain and Frailty in Childhood Cancer Survivors: A Narrative Review |
| title_full_unstemmed | Pain and Frailty in Childhood Cancer Survivors: A Narrative Review |
| title_short | Pain and Frailty in Childhood Cancer Survivors: A Narrative Review |
| title_sort | pain and frailty in childhood cancer survivors a narrative review |
| topic | pain frailty childhood cancer survivors |
| url | https://www.mdpi.com/1718-7729/32/1/22 |
| work_keys_str_mv | AT chiarapapini painandfrailtyinchildhoodcancersurvivorsanarrativereview AT jaspreetksodhi painandfrailtyinchildhoodcancersurvivorsanarrativereview AT cassiemargenbright painandfrailtyinchildhoodcancersurvivorsanarrativereview AT kirstenkness painandfrailtyinchildhoodcancersurvivorsanarrativereview AT tarambrinkman painandfrailtyinchildhoodcancersurvivorsanarrativereview |