Increased Serum ANGPTL8 Concentrations in Patients with Prediabetes and Type 2 Diabetes
The objectives of the study were to investigate serum ANGPTL8 concentrations in different glucose metabolic statuses and to explore the correlations between serum ANGPTL8 levels and various metabolic parameters. Serum ANGPTL8 levels were determined using ELISA in 22 subjects with NGT (normal glucose...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/8293207 |
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| author | Yanhua Yin Xiaoying Ding Liang Peng Yanqiang Hou Yunxia Ling Mingyu Gu Yufan Wang Yongde Peng Haiyan Sun |
| author_facet | Yanhua Yin Xiaoying Ding Liang Peng Yanqiang Hou Yunxia Ling Mingyu Gu Yufan Wang Yongde Peng Haiyan Sun |
| author_sort | Yanhua Yin |
| collection | DOAJ |
| description | The objectives of the study were to investigate serum ANGPTL8 concentrations in different glucose metabolic statuses and to explore the correlations between serum ANGPTL8 levels and various metabolic parameters. Serum ANGPTL8 levels were determined using ELISA in 22 subjects with NGT (normal glucose tolerance), 74 subjects with IGR (impaired glucose regulation), and 33 subjects with T2DM (type 2 diabetes mellitus). Subjects with IFG, IGT, CGI, and T2DM had higher levels of serum ANGPTL8 than subjects with NGT. Serum ANGPTL8 was positively correlated with FPG, fasting C-peptide, and postprandial C-peptide and negatively correlated with BETA/IR when adjusted for age and BMI. Multivariate analysis suggested FPG and fasting C-peptide as independent factors associated with serum ANGPTL8 levels. Serum ANGPTL8 concentrations were significantly increased in IGR and T2DM. Serum ANGPTL8 might play a role in the pathological mechanism of glucose intolerance. |
| format | Article |
| id | doaj-art-d31f996e11ea45a3bbcd9c9d43f8d46c |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-d31f996e11ea45a3bbcd9c9d43f8d46c2025-02-03T05:52:05ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/82932078293207Increased Serum ANGPTL8 Concentrations in Patients with Prediabetes and Type 2 DiabetesYanhua Yin0Xiaoying Ding1Liang Peng2Yanqiang Hou3Yunxia Ling4Mingyu Gu5Yufan Wang6Yongde Peng7Haiyan Sun8Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaDepartment of Clinical Laboratory Center, Shanghai Songjiang District Central Hospital, Shanghai 200080, ChinaDepartment of Clinical Laboratory Center, Shanghai Songjiang District Central Hospital, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, ChinaThe objectives of the study were to investigate serum ANGPTL8 concentrations in different glucose metabolic statuses and to explore the correlations between serum ANGPTL8 levels and various metabolic parameters. Serum ANGPTL8 levels were determined using ELISA in 22 subjects with NGT (normal glucose tolerance), 74 subjects with IGR (impaired glucose regulation), and 33 subjects with T2DM (type 2 diabetes mellitus). Subjects with IFG, IGT, CGI, and T2DM had higher levels of serum ANGPTL8 than subjects with NGT. Serum ANGPTL8 was positively correlated with FPG, fasting C-peptide, and postprandial C-peptide and negatively correlated with BETA/IR when adjusted for age and BMI. Multivariate analysis suggested FPG and fasting C-peptide as independent factors associated with serum ANGPTL8 levels. Serum ANGPTL8 concentrations were significantly increased in IGR and T2DM. Serum ANGPTL8 might play a role in the pathological mechanism of glucose intolerance.http://dx.doi.org/10.1155/2017/8293207 |
| spellingShingle | Yanhua Yin Xiaoying Ding Liang Peng Yanqiang Hou Yunxia Ling Mingyu Gu Yufan Wang Yongde Peng Haiyan Sun Increased Serum ANGPTL8 Concentrations in Patients with Prediabetes and Type 2 Diabetes Journal of Diabetes Research |
| title | Increased Serum ANGPTL8 Concentrations in Patients with Prediabetes and Type 2 Diabetes |
| title_full | Increased Serum ANGPTL8 Concentrations in Patients with Prediabetes and Type 2 Diabetes |
| title_fullStr | Increased Serum ANGPTL8 Concentrations in Patients with Prediabetes and Type 2 Diabetes |
| title_full_unstemmed | Increased Serum ANGPTL8 Concentrations in Patients with Prediabetes and Type 2 Diabetes |
| title_short | Increased Serum ANGPTL8 Concentrations in Patients with Prediabetes and Type 2 Diabetes |
| title_sort | increased serum angptl8 concentrations in patients with prediabetes and type 2 diabetes |
| url | http://dx.doi.org/10.1155/2017/8293207 |
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