Uncovering the genetic basis of antiviral polyketide limocrocin biosynthesis through heterologous expression
Abstract Background Streptomyces roseochromogenes NRRL 3504 produces clorobiocin, an aminocoumarin antibiotic that inhibits DNA replication. No other natural products have been isolated from this bacterium so far, despite the presence of a rich repertoire of specialized metabolite biosynthesis gene...
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Main Authors: | Sofiia Melnyk, Marc Stierhof, Dmytro Bratiichuk, Franziska Fries, Rolf Müller, Yuriy Rebets, Andriy Luzhetskyy, Bohdan Ostash |
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Format: | Article |
Language: | English |
Published: |
BMC
2025-01-01
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Series: | Microbial Cell Factories |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12934-024-02621-9 |
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