Uncovering the genetic basis of antiviral polyketide limocrocin biosynthesis through heterologous expression

Uncovering the genetic basis of antiviral polyketide limocrocin biosynthesis through heterologous expression

Abstract Background Streptomyces roseochromogenes NRRL 3504 produces clorobiocin, an aminocoumarin antibiotic that inhibits DNA replication. No other natural products have been isolated from this bacterium so far, despite the presence of a rich repertoire of specialized metabolite biosynthesis gene...

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Main Authors: Sofiia Melnyk, Marc Stierhof, Dmytro Bratiichuk, Franziska Fries, Rolf Müller, Yuriy Rebets, Andriy Luzhetskyy, Bohdan Ostash
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Microbial Cell Factories
Subjects:
Limocrocin
Genes
Heterologous expression
Biosynthetic gene cluster
Reverse transcriptase inhibitor
Online Access:https://doi.org/10.1186/s12934-024-02621-9
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https://doi.org/10.1186/s12934-024-02621-9

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