A Rapid Biochemical and Radiological Response to the Concomitant Therapy with Temozolomide and Radiotherapy in an Aggressive ACTH Pituitary Adenoma
Background and Importance. In the last eight years temozolomide (TMZ) has been used as the last-line treatment modality for aggressive pituitary tumors to be applied after the failure of surgery, medical therapy, and radiotherapy. The objective was to achieve a rapid control of tumor growth and horm...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/2419590 |
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| author | Ana Misir Krpan Tina Dusek Zoran Rakusic Mirsala Solak Ivana Kraljevic Vesna Bisof David Ozretic Darko Kastelan |
| author_facet | Ana Misir Krpan Tina Dusek Zoran Rakusic Mirsala Solak Ivana Kraljevic Vesna Bisof David Ozretic Darko Kastelan |
| author_sort | Ana Misir Krpan |
| collection | DOAJ |
| description | Background and Importance. In the last eight years temozolomide (TMZ) has been used as the last-line treatment modality for aggressive pituitary tumors to be applied after the failure of surgery, medical therapy, and radiotherapy. The objective was to achieve a rapid control of tumor growth and hormone normalization with concurrent chemoradiotherapy in a patient with very aggressive ACTH pituitary adenoma. Clinical Presentation. We describe a patient with an aggressive ACTH-producing adenoma treated with concurrent temozolomide and radiotherapy. The patient suffered from an aggressive ACTH adenoma resistant to surgical and medical treatment. After two months of concurrent temozolomide and radiotherapy, cortisol normalization and significant tumor shrinkage were observed. After 22 months of follow-up, there is still no evidence of tumor recurrence. Conclusion. Concurrent treatment with temozolomide and irradiation appears to be highly effective in the achievement of the tumor volume control as well as in the control of ACTH secretion in aggressive ACTH adenoma. |
| format | Article |
| id | doaj-art-d311f429df8245cd9ffa0794a6620b13 |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-d311f429df8245cd9ffa0794a6620b132025-02-03T06:44:28ZengWileyCase Reports in Endocrinology2090-65012090-651X2017-01-01201710.1155/2017/24195902419590A Rapid Biochemical and Radiological Response to the Concomitant Therapy with Temozolomide and Radiotherapy in an Aggressive ACTH Pituitary AdenomaAna Misir Krpan0Tina Dusek1Zoran Rakusic2Mirsala Solak3Ivana Kraljevic4Vesna Bisof5David Ozretic6Darko Kastelan7Department of Oncology, University Hospital Center Zagreb, Kispaticeva 12, 10000 Zagreb, CroatiaZagreb University School of Medicine, Department of Endocrinology, University Hospital Center Zagreb, Kispaticeva 12, 10000 Zagreb, CroatiaDepartment of Oncology, University Hospital Center Zagreb, Kispaticeva 12, 10000 Zagreb, CroatiaDepartment of Endocrinology, University Hospital Center Zagreb, Kispaticeva 12, 10000 Zagreb, CroatiaDepartment of Endocrinology, University Hospital Center Zagreb, Kispaticeva 12, 10000 Zagreb, CroatiaOsijek University School of Medicine, Department of Oncology, University Hospital Center Zagreb, Kispaticeva 12, 10000 Zagreb, CroatiaDepartment of Radiology, University Hospital Center Zagreb, Kispaticeva 12, 10000 Zagreb, CroatiaZagreb University School of Medicine, Department of Endocrinology, University Hospital Center Zagreb, Kispaticeva 12, 10000 Zagreb, CroatiaBackground and Importance. In the last eight years temozolomide (TMZ) has been used as the last-line treatment modality for aggressive pituitary tumors to be applied after the failure of surgery, medical therapy, and radiotherapy. The objective was to achieve a rapid control of tumor growth and hormone normalization with concurrent chemoradiotherapy in a patient with very aggressive ACTH pituitary adenoma. Clinical Presentation. We describe a patient with an aggressive ACTH-producing adenoma treated with concurrent temozolomide and radiotherapy. The patient suffered from an aggressive ACTH adenoma resistant to surgical and medical treatment. After two months of concurrent temozolomide and radiotherapy, cortisol normalization and significant tumor shrinkage were observed. After 22 months of follow-up, there is still no evidence of tumor recurrence. Conclusion. Concurrent treatment with temozolomide and irradiation appears to be highly effective in the achievement of the tumor volume control as well as in the control of ACTH secretion in aggressive ACTH adenoma.http://dx.doi.org/10.1155/2017/2419590 |
| spellingShingle | Ana Misir Krpan Tina Dusek Zoran Rakusic Mirsala Solak Ivana Kraljevic Vesna Bisof David Ozretic Darko Kastelan A Rapid Biochemical and Radiological Response to the Concomitant Therapy with Temozolomide and Radiotherapy in an Aggressive ACTH Pituitary Adenoma Case Reports in Endocrinology |
| title | A Rapid Biochemical and Radiological Response to the Concomitant Therapy with Temozolomide and Radiotherapy in an Aggressive ACTH Pituitary Adenoma |
| title_full | A Rapid Biochemical and Radiological Response to the Concomitant Therapy with Temozolomide and Radiotherapy in an Aggressive ACTH Pituitary Adenoma |
| title_fullStr | A Rapid Biochemical and Radiological Response to the Concomitant Therapy with Temozolomide and Radiotherapy in an Aggressive ACTH Pituitary Adenoma |
| title_full_unstemmed | A Rapid Biochemical and Radiological Response to the Concomitant Therapy with Temozolomide and Radiotherapy in an Aggressive ACTH Pituitary Adenoma |
| title_short | A Rapid Biochemical and Radiological Response to the Concomitant Therapy with Temozolomide and Radiotherapy in an Aggressive ACTH Pituitary Adenoma |
| title_sort | rapid biochemical and radiological response to the concomitant therapy with temozolomide and radiotherapy in an aggressive acth pituitary adenoma |
| url | http://dx.doi.org/10.1155/2017/2419590 |
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