Increased Serum Pigment Epithelium-Derived Factor in Women with Gestational Diabetes Is Associated with Type 2 Diabetes
Background. Pigment epithelium-derived factor (PEDF) is demonstrated to be elevated in diabetes patients. However, no reports have emerged in pregnant women with gestational diabetes mellitus (GDM). This study was undertaken to investigate serum PEDF levels in GDM women and to evaluate PEDF as a bio...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/346938 |
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| author | Tong-Huan Li Chun-Jian Qiu Xiao-Juan Yu Dan-Dan Liu Peng-Fei Zhou Liang Wu |
| author_facet | Tong-Huan Li Chun-Jian Qiu Xiao-Juan Yu Dan-Dan Liu Peng-Fei Zhou Liang Wu |
| author_sort | Tong-Huan Li |
| collection | DOAJ |
| description | Background. Pigment epithelium-derived factor (PEDF) is demonstrated to be elevated in diabetes patients. However, no reports have emerged in pregnant women with gestational diabetes mellitus (GDM). This study was undertaken to investigate serum PEDF levels in GDM women and to evaluate PEDF as a biomarker to predict diabetes postpartum. Methods. Serum PEDF concentration and clinical characteristics were detected in the pregnant women with GDM (n = 120) and without GDM (control group, n = 120). Results. PEDF levels were elevated in subjects with GDM versus controls. Univariate correlations showed that serum PEDF levels were positively correlated with fasting glucose and fasting insulin levels, respectively, and negatively correlated with adiponectin. Receiver operating characteristic (ROC) analysis demonstrated that the AUC of serum PEDF for diabetes mellitus in women postpartum was 0.893. Conclusion. Serum PEDF was elevated in pregnant women with GDM, which is probably an early detection marker for predicting development of GDM to diabetes mellitus. |
| format | Article |
| id | doaj-art-d309115dcc2a421f9561f0059eb2f79c |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-d309115dcc2a421f9561f0059eb2f79c2025-02-03T00:59:53ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/346938346938Increased Serum Pigment Epithelium-Derived Factor in Women with Gestational Diabetes Is Associated with Type 2 DiabetesTong-Huan Li0Chun-Jian Qiu1Xiao-Juan Yu2Dan-Dan Liu3Peng-Fei Zhou4Liang Wu5Department of Endocrinology, No. 81 Hospital of PLA, Nanjing 210002, ChinaDepartment of Endocrinology, No. 81 Hospital of PLA, Nanjing 210002, ChinaDepartment of Endocrinology, No. 81 Hospital of PLA, Nanjing 210002, ChinaDepartment of Endocrinology, No. 81 Hospital of PLA, Nanjing 210002, ChinaDepartment of Endocrinology, No. 81 Hospital of PLA, Nanjing 210002, ChinaDepartment of Endocrinology, No. 81 Hospital of PLA, Nanjing 210002, ChinaBackground. Pigment epithelium-derived factor (PEDF) is demonstrated to be elevated in diabetes patients. However, no reports have emerged in pregnant women with gestational diabetes mellitus (GDM). This study was undertaken to investigate serum PEDF levels in GDM women and to evaluate PEDF as a biomarker to predict diabetes postpartum. Methods. Serum PEDF concentration and clinical characteristics were detected in the pregnant women with GDM (n = 120) and without GDM (control group, n = 120). Results. PEDF levels were elevated in subjects with GDM versus controls. Univariate correlations showed that serum PEDF levels were positively correlated with fasting glucose and fasting insulin levels, respectively, and negatively correlated with adiponectin. Receiver operating characteristic (ROC) analysis demonstrated that the AUC of serum PEDF for diabetes mellitus in women postpartum was 0.893. Conclusion. Serum PEDF was elevated in pregnant women with GDM, which is probably an early detection marker for predicting development of GDM to diabetes mellitus.http://dx.doi.org/10.1155/2015/346938 |
| spellingShingle | Tong-Huan Li Chun-Jian Qiu Xiao-Juan Yu Dan-Dan Liu Peng-Fei Zhou Liang Wu Increased Serum Pigment Epithelium-Derived Factor in Women with Gestational Diabetes Is Associated with Type 2 Diabetes International Journal of Endocrinology |
| title | Increased Serum Pigment Epithelium-Derived Factor in Women with Gestational Diabetes Is Associated with Type 2 Diabetes |
| title_full | Increased Serum Pigment Epithelium-Derived Factor in Women with Gestational Diabetes Is Associated with Type 2 Diabetes |
| title_fullStr | Increased Serum Pigment Epithelium-Derived Factor in Women with Gestational Diabetes Is Associated with Type 2 Diabetes |
| title_full_unstemmed | Increased Serum Pigment Epithelium-Derived Factor in Women with Gestational Diabetes Is Associated with Type 2 Diabetes |
| title_short | Increased Serum Pigment Epithelium-Derived Factor in Women with Gestational Diabetes Is Associated with Type 2 Diabetes |
| title_sort | increased serum pigment epithelium derived factor in women with gestational diabetes is associated with type 2 diabetes |
| url | http://dx.doi.org/10.1155/2015/346938 |
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