Family History of Diabetes and the Effectiveness of Lifestyle Intervention on Insulin Secretion and Insulin Resistance in Chinese Individuals with Metabolic Syndrome
Aims. The current study aims to explore if a family history of diabetes can influence the efficiency of lifestyle intervention on insulin secretion and study the insulin resistance in Chinese men and women with metabolic syndrome in a cohort with a 2-year follow-up. Methods. 151 individuals (90 indi...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/8822702 |
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| author | Haiqing Zhu Xiaoping Chen Bo Zhang Wenying Yang Xiaoyan Xing |
| author_facet | Haiqing Zhu Xiaoping Chen Bo Zhang Wenying Yang Xiaoyan Xing |
| author_sort | Haiqing Zhu |
| collection | DOAJ |
| description | Aims. The current study aims to explore if a family history of diabetes can influence the efficiency of lifestyle intervention on insulin secretion and study the insulin resistance in Chinese men and women with metabolic syndrome in a cohort with a 2-year follow-up. Methods. 151 individuals (90 individuals did not have a family history of diabetes (DMFH (-)) and 61 with a family history of diabetes (DMFH (+)) with metabolic syndrome participated in the lifestyle intervention program at baseline and finished with 1-year follow-up. 124 individuals have two-year follow-up data. A family history of diabetes was ascertained by self-report. Lifestyle interventions were individual sessions on lifestyle changes. Results. During the 1-year follow-up, Ln Insulinogenic index (Δbaseline−1year=0.29±0.65, P=0.001) and 30-min glucose (Δbaseline−1year=−0.41±1.71, P=0.024) changed significantly in the DMFH(-) group; in the DMFH(+) group, Ln ISIm (Δbaseline−1year=−0.22±0.60, P=0.022) and 30-min glucose (Δbaseline−1year=0.53±1.89, P=0.032) changed significantly, and there was no significant change of other parameters. The change of 30 min glucose during a 1-year intervention has shown a significant difference between the two groups (P=0.002). During the 2 years intervention, Ln Insulinogenic index changed significantly in the DMFH(-) group (Δbaseline−1year=0.33±0.66, P<0.001 and Δbaseline−2year=0.43±1.17, P=0.034). Fasting insulin (Δbaseline−2year=2.95±8.69, P=0.034), 2 h insulin (Δbaseline−2year=23.75±44.89, P=0.002), Ln HOMA-B (Δbaseline−2year=0.43±1.02, P=0.009), Ln HOMA-IR (Δbaseline−2year=0.53±1.04, P=0.002), Ln ISIm (Δbaseline−2year=0.52±0.95, P=0.004), and Ln Insulinogenic index (Δbaseline−2year=0.66±1.18, P=0.047) changed significantly after 2 years of intervention, compared to the baseline in the DMFH(+) group. The change of Ln ISIm (P=0.023), fasting (P=0.030), and 2 h insulin (P=0.007) during the 2-year intervention has shown a significant difference between the two groups. Family history of diabetes was related with a 0.500 unit increase in 2-year ISIm (P=0.020) modified by lifestyle intervention adjusted for age, baseline BMI, sex, and baseline waist circumference and a 0.476 unit increase in 2-year ISIm (P=0.027) with extra adjustment for weight change. Conclusions. Patients with a family history of diabetes benefit more from lifestyle intervention in regard to insulin resistance than those without a family history of diabetes adjusting for age, baseline BMI, sex, baseline waist circumference, and weight change. |
| format | Article |
| id | doaj-art-d2e8d345078e44b9838fbe40e88a7e09 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
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| series | Journal of Diabetes Research |
| spelling | doaj-art-d2e8d345078e44b9838fbe40e88a7e092025-08-20T03:24:07ZengWileyJournal of Diabetes Research2314-67452314-67532021-01-01202110.1155/2021/88227028822702Family History of Diabetes and the Effectiveness of Lifestyle Intervention on Insulin Secretion and Insulin Resistance in Chinese Individuals with Metabolic SyndromeHaiqing Zhu0Xiaoping Chen1Bo Zhang2Wenying Yang3Xiaoyan Xing4Department of Endocrinology, Emergency General Hospital, Beijing, ChinaDepartment of Endocrinology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Endocrinology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Endocrinology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Endocrinology, China-Japan Friendship Hospital, Beijing, ChinaAims. The current study aims to explore if a family history of diabetes can influence the efficiency of lifestyle intervention on insulin secretion and study the insulin resistance in Chinese men and women with metabolic syndrome in a cohort with a 2-year follow-up. Methods. 151 individuals (90 individuals did not have a family history of diabetes (DMFH (-)) and 61 with a family history of diabetes (DMFH (+)) with metabolic syndrome participated in the lifestyle intervention program at baseline and finished with 1-year follow-up. 124 individuals have two-year follow-up data. A family history of diabetes was ascertained by self-report. Lifestyle interventions were individual sessions on lifestyle changes. Results. During the 1-year follow-up, Ln Insulinogenic index (Δbaseline−1year=0.29±0.65, P=0.001) and 30-min glucose (Δbaseline−1year=−0.41±1.71, P=0.024) changed significantly in the DMFH(-) group; in the DMFH(+) group, Ln ISIm (Δbaseline−1year=−0.22±0.60, P=0.022) and 30-min glucose (Δbaseline−1year=0.53±1.89, P=0.032) changed significantly, and there was no significant change of other parameters. The change of 30 min glucose during a 1-year intervention has shown a significant difference between the two groups (P=0.002). During the 2 years intervention, Ln Insulinogenic index changed significantly in the DMFH(-) group (Δbaseline−1year=0.33±0.66, P<0.001 and Δbaseline−2year=0.43±1.17, P=0.034). Fasting insulin (Δbaseline−2year=2.95±8.69, P=0.034), 2 h insulin (Δbaseline−2year=23.75±44.89, P=0.002), Ln HOMA-B (Δbaseline−2year=0.43±1.02, P=0.009), Ln HOMA-IR (Δbaseline−2year=0.53±1.04, P=0.002), Ln ISIm (Δbaseline−2year=0.52±0.95, P=0.004), and Ln Insulinogenic index (Δbaseline−2year=0.66±1.18, P=0.047) changed significantly after 2 years of intervention, compared to the baseline in the DMFH(+) group. The change of Ln ISIm (P=0.023), fasting (P=0.030), and 2 h insulin (P=0.007) during the 2-year intervention has shown a significant difference between the two groups. Family history of diabetes was related with a 0.500 unit increase in 2-year ISIm (P=0.020) modified by lifestyle intervention adjusted for age, baseline BMI, sex, and baseline waist circumference and a 0.476 unit increase in 2-year ISIm (P=0.027) with extra adjustment for weight change. Conclusions. Patients with a family history of diabetes benefit more from lifestyle intervention in regard to insulin resistance than those without a family history of diabetes adjusting for age, baseline BMI, sex, baseline waist circumference, and weight change.http://dx.doi.org/10.1155/2021/8822702 |
| spellingShingle | Haiqing Zhu Xiaoping Chen Bo Zhang Wenying Yang Xiaoyan Xing Family History of Diabetes and the Effectiveness of Lifestyle Intervention on Insulin Secretion and Insulin Resistance in Chinese Individuals with Metabolic Syndrome Journal of Diabetes Research |
| title | Family History of Diabetes and the Effectiveness of Lifestyle Intervention on Insulin Secretion and Insulin Resistance in Chinese Individuals with Metabolic Syndrome |
| title_full | Family History of Diabetes and the Effectiveness of Lifestyle Intervention on Insulin Secretion and Insulin Resistance in Chinese Individuals with Metabolic Syndrome |
| title_fullStr | Family History of Diabetes and the Effectiveness of Lifestyle Intervention on Insulin Secretion and Insulin Resistance in Chinese Individuals with Metabolic Syndrome |
| title_full_unstemmed | Family History of Diabetes and the Effectiveness of Lifestyle Intervention on Insulin Secretion and Insulin Resistance in Chinese Individuals with Metabolic Syndrome |
| title_short | Family History of Diabetes and the Effectiveness of Lifestyle Intervention on Insulin Secretion and Insulin Resistance in Chinese Individuals with Metabolic Syndrome |
| title_sort | family history of diabetes and the effectiveness of lifestyle intervention on insulin secretion and insulin resistance in chinese individuals with metabolic syndrome |
| url | http://dx.doi.org/10.1155/2021/8822702 |
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