Integrated Evaluation of Age-Related Changes in Structural and Functional Vascular Parameters Used to Assess Arterial Aging, Subclinical Atherosclerosis, and Cardiovascular Risk in Uruguayan Adults: CUiiDARTE Project
This work was carried out in a Uruguayan (South American) population to characterize aging-associated physiological arterial changes. Parameters markers of subclinical atherosclerosis and that associate age-related changes were evaluated in healthy people. A conservative approach was used and people...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.4061/2011/587303 |
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| author | Daniel Bia Yanina Zócalo Ignacio Farro Juan Torrado Federico Farro Lucía Florio Alicia Olascoaga Javier Brum Walter Alallón Carlos Negreira Ricardo Lluberas Ricardo L. Armentano |
| author_facet | Daniel Bia Yanina Zócalo Ignacio Farro Juan Torrado Federico Farro Lucía Florio Alicia Olascoaga Javier Brum Walter Alallón Carlos Negreira Ricardo Lluberas Ricardo L. Armentano |
| author_sort | Daniel Bia |
| collection | DOAJ |
| description | This work was carried out in a Uruguayan (South American) population to characterize aging-associated physiological arterial changes. Parameters markers of subclinical atherosclerosis and that associate age-related changes were evaluated in healthy people. A conservative approach was used and people with nonphysiological and pathological conditions were excluded. Then, we excluded subjects with (a) cardiovascular (CV) symptoms, (b) CV disease, (c) diabetes mellitus or renal failure, and (d) traditional CV risk factors (other than age and gender). Subjects (n=388) were submitted to non-invasive vascular studies (gold-standard techniques), to evaluate (1) common (CCA), internal, and external carotid plaque prevalence, (2) CCA intima-media thickness and diameter, (3) CCA stiffness (percentual pulsatility, compliance, distensibility, and stiffness index), (4) aortic stiffness (carotid-femoral pulse wave velocity), and (5) peripheral and central pressure wave-derived parameters. Age groups: ≤20, 21–30, 31–40, 41–50, 51–60, 61–70, and 71–80 years old. Age-related structural and functional vascular parameters profiles were obtained and analyzed considering data from other populations. The work has the strength of being the first, in Latin America, that uses an integrative approach to characterize vascular aging-related changes. Data could be used to define vascular aging and abnormal or disease-related changes. |
| format | Article |
| id | doaj-art-d2d6b9544f40438fbe289b979b3e5232 |
| institution | Kabale University |
| issn | 2090-0392 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-d2d6b9544f40438fbe289b979b3e52322025-02-03T06:12:41ZengWileyInternational Journal of Hypertension2090-03922011-01-01201110.4061/2011/587303587303Integrated Evaluation of Age-Related Changes in Structural and Functional Vascular Parameters Used to Assess Arterial Aging, Subclinical Atherosclerosis, and Cardiovascular Risk in Uruguayan Adults: CUiiDARTE ProjectDaniel Bia0Yanina Zócalo1Ignacio Farro2Juan Torrado3Federico Farro4Lucía Florio5Alicia Olascoaga6Javier Brum7Walter Alallón8Carlos Negreira9Ricardo Lluberas10Ricardo L. Armentano11Physiology Department, School of Medicine and School of Science, CUiiDARTE, Republic University, General Flores 2125, 11800 Montevideo, UruguayPhysiology Department, School of Medicine and School of Science, CUiiDARTE, Republic University, General Flores 2125, 11800 Montevideo, UruguayPhysiology Department, School of Medicine and School of Science, CUiiDARTE, Republic University, General Flores 2125, 11800 Montevideo, UruguayPhysiology Department, School of Medicine and School of Science, CUiiDARTE, Republic University, General Flores 2125, 11800 Montevideo, UruguayPhysiology Department, School of Medicine and School of Science, CUiiDARTE, Republic University, General Flores 2125, 11800 Montevideo, UruguayCardiology Department, Cardiovascular Centre, School of Medicine, CUiiDARTE, Clinical Hospital, Republic University, Avenida Italia s/n, 11600 Montevideo, UruguayClinical Laboratory Department, School of Medicine, Clinical Hospital, Republic University, Avenida Italia s/n, 11600 Montevideo, UruguayPhysics Institute, School of Sciences, CUiiDARTE, Republic University, Iguá 4225, 11400 Montevideo, UruguayClinical Laboratory Department, School of Medicine, Clinical Hospital, Republic University, Avenida Italia s/n, 11600 Montevideo, UruguayPhysics Institute, School of Sciences, CUiiDARTE, Republic University, Iguá 4225, 11400 Montevideo, UruguayCardiology Department, Cardiovascular Centre, School of Medicine, CUiiDARTE, Clinical Hospital, Republic University, Avenida Italia s/n, 11600 Montevideo, UruguayPhysiology Department, School of Medicine and School of Science, CUiiDARTE, Republic University, General Flores 2125, 11800 Montevideo, UruguayThis work was carried out in a Uruguayan (South American) population to characterize aging-associated physiological arterial changes. Parameters markers of subclinical atherosclerosis and that associate age-related changes were evaluated in healthy people. A conservative approach was used and people with nonphysiological and pathological conditions were excluded. Then, we excluded subjects with (a) cardiovascular (CV) symptoms, (b) CV disease, (c) diabetes mellitus or renal failure, and (d) traditional CV risk factors (other than age and gender). Subjects (n=388) were submitted to non-invasive vascular studies (gold-standard techniques), to evaluate (1) common (CCA), internal, and external carotid plaque prevalence, (2) CCA intima-media thickness and diameter, (3) CCA stiffness (percentual pulsatility, compliance, distensibility, and stiffness index), (4) aortic stiffness (carotid-femoral pulse wave velocity), and (5) peripheral and central pressure wave-derived parameters. Age groups: ≤20, 21–30, 31–40, 41–50, 51–60, 61–70, and 71–80 years old. Age-related structural and functional vascular parameters profiles were obtained and analyzed considering data from other populations. The work has the strength of being the first, in Latin America, that uses an integrative approach to characterize vascular aging-related changes. Data could be used to define vascular aging and abnormal or disease-related changes.http://dx.doi.org/10.4061/2011/587303 |
| spellingShingle | Daniel Bia Yanina Zócalo Ignacio Farro Juan Torrado Federico Farro Lucía Florio Alicia Olascoaga Javier Brum Walter Alallón Carlos Negreira Ricardo Lluberas Ricardo L. Armentano Integrated Evaluation of Age-Related Changes in Structural and Functional Vascular Parameters Used to Assess Arterial Aging, Subclinical Atherosclerosis, and Cardiovascular Risk in Uruguayan Adults: CUiiDARTE Project International Journal of Hypertension |
| title | Integrated Evaluation of Age-Related Changes in Structural and Functional Vascular Parameters Used to Assess Arterial Aging, Subclinical Atherosclerosis, and Cardiovascular Risk in Uruguayan Adults: CUiiDARTE Project |
| title_full | Integrated Evaluation of Age-Related Changes in Structural and Functional Vascular Parameters Used to Assess Arterial Aging, Subclinical Atherosclerosis, and Cardiovascular Risk in Uruguayan Adults: CUiiDARTE Project |
| title_fullStr | Integrated Evaluation of Age-Related Changes in Structural and Functional Vascular Parameters Used to Assess Arterial Aging, Subclinical Atherosclerosis, and Cardiovascular Risk in Uruguayan Adults: CUiiDARTE Project |
| title_full_unstemmed | Integrated Evaluation of Age-Related Changes in Structural and Functional Vascular Parameters Used to Assess Arterial Aging, Subclinical Atherosclerosis, and Cardiovascular Risk in Uruguayan Adults: CUiiDARTE Project |
| title_short | Integrated Evaluation of Age-Related Changes in Structural and Functional Vascular Parameters Used to Assess Arterial Aging, Subclinical Atherosclerosis, and Cardiovascular Risk in Uruguayan Adults: CUiiDARTE Project |
| title_sort | integrated evaluation of age related changes in structural and functional vascular parameters used to assess arterial aging subclinical atherosclerosis and cardiovascular risk in uruguayan adults cuiidarte project |
| url | http://dx.doi.org/10.4061/2011/587303 |
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