RNF128 deficiency in macrophages promotes colonic inflammation by suppressing the autophagic degradation of S100A8

RNF128 deficiency in macrophages promotes colonic inflammation by suppressing the autophagic degradation of S100A8

Abstract Macrophages play important roles in maintaining intestinal homeostasis and in the pathogenesis of inflammatory bowel diseases (IBDs). However, the underlying mechanisms that govern macrophage-mediated inflammation are still largely unknown. In this study, we report that RNF128 is downregula...

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Bibliographic Details
Main Authors: Xianwen Ran, Yue Li, Yahui Ren, Weilong Chang, Rui Deng, Huifen Wang, Weiwei Zhu, Yize Zhang, Yudie Cai, Jia Hu, Di Wang, Zhibo Liu
Format: Article
Language:English
Published: Nature Publishing Group 2025-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07338-0
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