Enhancing Neuroplasticity for Post-Stroke Motor Recovery: Mechanisms, Models, and Neurotechnology
Stroke remains a significant global health challenge, imposing substantial socioeconomic burdens. Post-stroke neurorehabilitation aims to maximize functional recovery and mitigate persistent disability through effective neuromodulation, while many patients experience prolonged recovery periods with...
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| Format: | Article |
| Language: | English |
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IEEE
2025-01-01
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| Series: | IEEE Transactions on Neural Systems and Rehabilitation Engineering |
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| Online Access: | https://ieeexplore.ieee.org/document/10929703/ |
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| author | Wangwang Yan Yuzhou Lin Yi-Feng Chen Yuling Wang Jingxin Wang Mingming Zhang |
| author_facet | Wangwang Yan Yuzhou Lin Yi-Feng Chen Yuling Wang Jingxin Wang Mingming Zhang |
| author_sort | Wangwang Yan |
| collection | DOAJ |
| description | Stroke remains a significant global health challenge, imposing substantial socioeconomic burdens. Post-stroke neurorehabilitation aims to maximize functional recovery and mitigate persistent disability through effective neuromodulation, while many patients experience prolonged recovery periods with suboptimal outcomes. This review explores innovative neurotechnologies and therapeutic strategies enhancing neuroplasticity for post-stroke motor recovery, with a particular focus on the subacute and chronic phases. We examine key neuroplasticity mechanisms and rehabilitation models informing neurotechnology use, including the vicariation model, the interhemispheric competition model, and the bimodal balance-recovery model. Building on these theoretical foundations, current neurotechnologies are categorized into endogenous drivers of neuroplasticity (e.g., task-oriented training, brain-computer interfaces) and exogenous drivers (e.g., brain stimulation, muscular electrical stimulation, robot-assisted passive movement). However, most approaches lack tailored adjustments combining volitional behavior with brain neuromodulation. Given the heterogeneous effects of current neurotechnologies, we propose that future directions should focus on personalized rehabilitation strategies and closed-loop neuromodulation. These advanced approaches may provide deeper insights into neuroplasticity and potentially expand recovery possibilities for stroke patients. |
| format | Article |
| id | doaj-art-d2d062cfc99b47b4af939e206a7e4211 |
| institution | DOAJ |
| issn | 1534-4320 1558-0210 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Transactions on Neural Systems and Rehabilitation Engineering |
| spelling | doaj-art-d2d062cfc99b47b4af939e206a7e42112025-08-20T02:40:32ZengIEEEIEEE Transactions on Neural Systems and Rehabilitation Engineering1534-43201558-02102025-01-01331156116810.1109/TNSRE.2025.355175310929703Enhancing Neuroplasticity for Post-Stroke Motor Recovery: Mechanisms, Models, and NeurotechnologyWangwang Yan0https://orcid.org/0000-0003-3147-8149Yuzhou Lin1https://orcid.org/0000-0003-3184-0523Yi-Feng Chen2https://orcid.org/0000-0002-2709-6036Yuling Wang3Jingxin Wang4Mingming Zhang5https://orcid.org/0000-0001-8016-1856Department of Biomedical Engineering, Shenzhen Key Laboratory of Smart Healthcare Engineering, Southern University of Science and Technology, Shenzhen, ChinaDepartment of Biomedical Engineering, Shenzhen Key Laboratory of Smart Healthcare Engineering, Southern University of Science and Technology, Shenzhen, ChinaDepartment of Biomedical Engineering, Shenzhen Key Laboratory of Smart Healthcare Engineering, Southern University of Science and Technology, Shenzhen, ChinaDepartment of Rehabilitation Medicine, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Rehabilitation Medicine, Zhengzhou Central Hospital Affiliated, Zhengzhou University, Zhengzhou, ChinaDepartment of Biomedical Engineering, Shenzhen Key Laboratory of Smart Healthcare Engineering, Southern University of Science and Technology, Shenzhen, ChinaStroke remains a significant global health challenge, imposing substantial socioeconomic burdens. Post-stroke neurorehabilitation aims to maximize functional recovery and mitigate persistent disability through effective neuromodulation, while many patients experience prolonged recovery periods with suboptimal outcomes. This review explores innovative neurotechnologies and therapeutic strategies enhancing neuroplasticity for post-stroke motor recovery, with a particular focus on the subacute and chronic phases. We examine key neuroplasticity mechanisms and rehabilitation models informing neurotechnology use, including the vicariation model, the interhemispheric competition model, and the bimodal balance-recovery model. Building on these theoretical foundations, current neurotechnologies are categorized into endogenous drivers of neuroplasticity (e.g., task-oriented training, brain-computer interfaces) and exogenous drivers (e.g., brain stimulation, muscular electrical stimulation, robot-assisted passive movement). However, most approaches lack tailored adjustments combining volitional behavior with brain neuromodulation. Given the heterogeneous effects of current neurotechnologies, we propose that future directions should focus on personalized rehabilitation strategies and closed-loop neuromodulation. These advanced approaches may provide deeper insights into neuroplasticity and potentially expand recovery possibilities for stroke patients.https://ieeexplore.ieee.org/document/10929703/Ischemic strokeneuroplasticityneurotechnologyrehabilitationmotor function |
| spellingShingle | Wangwang Yan Yuzhou Lin Yi-Feng Chen Yuling Wang Jingxin Wang Mingming Zhang Enhancing Neuroplasticity for Post-Stroke Motor Recovery: Mechanisms, Models, and Neurotechnology IEEE Transactions on Neural Systems and Rehabilitation Engineering Ischemic stroke neuroplasticity neurotechnology rehabilitation motor function |
| title | Enhancing Neuroplasticity for Post-Stroke Motor Recovery: Mechanisms, Models, and Neurotechnology |
| title_full | Enhancing Neuroplasticity for Post-Stroke Motor Recovery: Mechanisms, Models, and Neurotechnology |
| title_fullStr | Enhancing Neuroplasticity for Post-Stroke Motor Recovery: Mechanisms, Models, and Neurotechnology |
| title_full_unstemmed | Enhancing Neuroplasticity for Post-Stroke Motor Recovery: Mechanisms, Models, and Neurotechnology |
| title_short | Enhancing Neuroplasticity for Post-Stroke Motor Recovery: Mechanisms, Models, and Neurotechnology |
| title_sort | enhancing neuroplasticity for post stroke motor recovery mechanisms models and neurotechnology |
| topic | Ischemic stroke neuroplasticity neurotechnology rehabilitation motor function |
| url | https://ieeexplore.ieee.org/document/10929703/ |
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