Plasma and Fecal Metabolites Combined with Gut Microbiome Reveal Systemic Metabolic Shifts in <sup>60</sup>Co Gamma-Irradiated Rats

Plasma and Fecal Metabolites Combined with Gut Microbiome Reveal Systemic Metabolic Shifts in <sup>60</sup>Co Gamma-Irradiated Rats

<b>Background</b>: High-dose γ-ray exposure (≥7 Gy) in nuclear emergencies induces life-threatening acute radiation syndrome, characterized by rapid hematopoietic collapse (leukocytes <0.5 × 10⁹/L) and gastrointestinal barrier failure. While clinical biomarkers like leukocyte depletio...

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Main Authors: Jie Zong, Haiyang Wu, Xuan Hu, Ami Yao, Wenhua Zhu, Guifang Dou, Shuchen Liu, Xiaoxia Zhu, Ruolan Gu, Yunbo Sun, Zhuona Wu, Shanshan Wang, Hui Gan
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Metabolites
Subjects:
radiation
<sup>60</sup>Coγ-ray
untarget metabolomics
16S rRNA sequencing
gut microbiota
metabolic disruption
Online Access:https://www.mdpi.com/2218-1989/15/6/363
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