A novel TRKB-activating internal tandem duplication characterizes a new mechanism of receptor tyrosine kinase activation

A novel TRKB-activating internal tandem duplication characterizes a new mechanism of receptor tyrosine kinase activation

Abstract Precision medicine programs like the Zero Childhood Cancer Program perform comprehensive molecular analysis of patient tumors, enabling detection of novel structural variants that may be cryptic to standard techniques. Identification of these variants can impact individual patient treatment...

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Main Authors: Lauren M. Brown, Gabor Tax, Pablo Acera Mateos, Antoine de Weck, Steve Foresto, Thomas Robertson, Fatimah Jalud, Pamela Ajuyah, Paulette Barahona, Jie Mao, M. Emmy M. Dolman, Marie Wong, Chelsea Mayoh, Mark J. Cowley, Loretta M. S. Lau, Teresa Sadras, Paul G. Ekert
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00928-3
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