Dendritic cells immunotargeted therapy for atherosclerosis
Atherosclerosis, a chronic inflammatory disease, is markedly influenced by both immune and inflammatory reactions throughout its progression. Dendritic cells, as pivotal antigen-presenting entities, play a crucial role in the initiation of immune responses and the preservation of immunological homeo...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Acta Pharmaceutica Sinica B |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383524004866 |
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| author | Zhaohui Li Yanyan Yang Jinbao Zong Bei Zhang Xiaolu Li Hongzhao Qi Tao Yu Yongxin Li |
| author_facet | Zhaohui Li Yanyan Yang Jinbao Zong Bei Zhang Xiaolu Li Hongzhao Qi Tao Yu Yongxin Li |
| author_sort | Zhaohui Li |
| collection | DOAJ |
| description | Atherosclerosis, a chronic inflammatory disease, is markedly influenced by both immune and inflammatory reactions throughout its progression. Dendritic cells, as pivotal antigen-presenting entities, play a crucial role in the initiation of immune responses and the preservation of immunological homeostasis. Accumulating data indicates that dendritic cells are present in healthy arteries and accumulate significantly in atherosclerotic plaques. Novel immunotherapeutic approaches and vaccination protocols have yielded substantial clinical advancements in managing chronic inflammatory diseases, with dendritic cell-centric modalities emerging for atherosclerotic management. In this review, we delineate the essential functions and underlying mechanisms of dendritic cells and their subsets in the modulation of atherosclerotic inflammation and immune responses. We underscore the immense promise of dendritic cell-based immunotherapeutic strategies, including vaccines and innovative combinations with nanotechnological drug delivery platforms for atherosclerosis treatment. We also discuss the challenges associated with dendritic cell immunotherapy and provide perspectives on the future direction of this field. |
| format | Article |
| id | doaj-art-d2c10c4b8be445ca859d24a27c5881d0 |
| institution | DOAJ |
| issn | 2211-3835 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj-art-d2c10c4b8be445ca859d24a27c5881d02025-08-20T02:47:37ZengElsevierActa Pharmaceutica Sinica B2211-38352025-02-0115279280810.1016/j.apsb.2024.12.029Dendritic cells immunotargeted therapy for atherosclerosisZhaohui Li0Yanyan Yang1Jinbao Zong2Bei Zhang3Xiaolu Li4Hongzhao Qi5Tao Yu6Yongxin Li7Department of Vascular Surgery, the Affiliated Hospital of Qingdao University, Qingdao, 266400, ChinaDepartment of Immunology, School of Basic Medicine, Qingdao University, Qingdao, 266071, ChinaClinical Laboratory, Central Laboratory, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital), Qingdao, 266000, ChinaDepartment of Immunology, School of Basic Medicine, Qingdao University, Qingdao, 266071, ChinaDepartment of Cardiac Ultrasound, the Affiliated Hospital of Qingdao University, Qingdao, 266000, ChinaInstitute for Translational Medicine, the Affiliated Hospital of Qingdao University, Qingdao, 266021, ChinaDepartment of Cardiac Ultrasound, the Affiliated Hospital of Qingdao University, Qingdao, 266000, China; Institute for Translational Medicine, the Affiliated Hospital of Qingdao University, Qingdao, 266021, China; Corresponding authors.Department of Vascular Surgery, the Affiliated Hospital of Qingdao University, Qingdao, 266400, China; Corresponding authors.Atherosclerosis, a chronic inflammatory disease, is markedly influenced by both immune and inflammatory reactions throughout its progression. Dendritic cells, as pivotal antigen-presenting entities, play a crucial role in the initiation of immune responses and the preservation of immunological homeostasis. Accumulating data indicates that dendritic cells are present in healthy arteries and accumulate significantly in atherosclerotic plaques. Novel immunotherapeutic approaches and vaccination protocols have yielded substantial clinical advancements in managing chronic inflammatory diseases, with dendritic cell-centric modalities emerging for atherosclerotic management. In this review, we delineate the essential functions and underlying mechanisms of dendritic cells and their subsets in the modulation of atherosclerotic inflammation and immune responses. We underscore the immense promise of dendritic cell-based immunotherapeutic strategies, including vaccines and innovative combinations with nanotechnological drug delivery platforms for atherosclerosis treatment. We also discuss the challenges associated with dendritic cell immunotherapy and provide perspectives on the future direction of this field.http://www.sciencedirect.com/science/article/pii/S2211383524004866Dendritic cellAtherosclerosisImmunotherapyInflammationDelivery |
| spellingShingle | Zhaohui Li Yanyan Yang Jinbao Zong Bei Zhang Xiaolu Li Hongzhao Qi Tao Yu Yongxin Li Dendritic cells immunotargeted therapy for atherosclerosis Acta Pharmaceutica Sinica B Dendritic cell Atherosclerosis Immunotherapy Inflammation Delivery |
| title | Dendritic cells immunotargeted therapy for atherosclerosis |
| title_full | Dendritic cells immunotargeted therapy for atherosclerosis |
| title_fullStr | Dendritic cells immunotargeted therapy for atherosclerosis |
| title_full_unstemmed | Dendritic cells immunotargeted therapy for atherosclerosis |
| title_short | Dendritic cells immunotargeted therapy for atherosclerosis |
| title_sort | dendritic cells immunotargeted therapy for atherosclerosis |
| topic | Dendritic cell Atherosclerosis Immunotherapy Inflammation Delivery |
| url | http://www.sciencedirect.com/science/article/pii/S2211383524004866 |
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