Opportunistic Infections in Patients with HTLV-1 Infection
As an acquired immunodeficiency, human immunodeficiency virus (HIV) infection is primarily responsible for opportunistic infections in infected patients. However, opportunistic infections also occur in individuals with human T cell lymphotrophic virus type 1 (HTLV-1) infection. Here, we report oppor...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2015/943867 |
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| author | Toshiki Tanaka Toshio Sekioka Masakatsu Usui Shinsaku Imashuku |
| author_facet | Toshiki Tanaka Toshio Sekioka Masakatsu Usui Shinsaku Imashuku |
| author_sort | Toshiki Tanaka |
| collection | DOAJ |
| description | As an acquired immunodeficiency, human immunodeficiency virus (HIV) infection is primarily responsible for opportunistic infections in infected patients. However, opportunistic infections also occur in individuals with human T cell lymphotrophic virus type 1 (HTLV-1) infection. Here, we report opportunistic infections in two Japanese HTLV-1-seropositive patients. The first patient was a 67-year-old male, who had cytomegalovirus infection associated with esophagogastritis and terminal ileitis. The patient was HTLV-1-positive and was diagnosed with smoldering adult T cell leukemia (ATL). High levels of serum soluble IL-2 receptor (sIL-2R; 4,304 U/mL) and an increased percentage of CD4+CD25+ T cells (75.5%) in peripheral blood were also detected. The second patient was a 78-year-old female, a known asymptomatic HTLV-1 carrier, who presented with persistent herpes zoster, followed by Pneumocystis jirovecii pneumonia. Disease progression of smoldering ATL along opportunistic infections was observed with very high levels of serum sIL-2R (14,058 U/mL) and an increased percentage of CD4+CD25+ T cells (87.2%) in peripheral blood. In patients with suspected opportunistic infections, both HTLV-1 and HIV should be considered. In HTLV-1-positive patients, an increase in the CD4+CD25+ T cell subset may have its value as a prognostic marker. |
| format | Article |
| id | doaj-art-d2bc5aff69084784bae9317374e3d6ca |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-d2bc5aff69084784bae9317374e3d6ca2025-02-03T05:51:27ZengWileyCase Reports in Hematology2090-65602090-65792015-01-01201510.1155/2015/943867943867Opportunistic Infections in Patients with HTLV-1 InfectionToshiki Tanaka0Toshio Sekioka1Masakatsu Usui2Shinsaku Imashuku3Department of Internal Medicine, Uji-Tokushukai Medical Center, Uji 611-0042, JapanDepartment of Internal Medicine, Uji-Tokushukai Medical Center, Uji 611-0042, JapanDepartment of Internal Medicine, Uji-Tokushukai Medical Center, Uji 611-0042, JapanDepartment of Laboratory Medicine, Uji-Tokushukai Medical Center, Uji 611-0042, JapanAs an acquired immunodeficiency, human immunodeficiency virus (HIV) infection is primarily responsible for opportunistic infections in infected patients. However, opportunistic infections also occur in individuals with human T cell lymphotrophic virus type 1 (HTLV-1) infection. Here, we report opportunistic infections in two Japanese HTLV-1-seropositive patients. The first patient was a 67-year-old male, who had cytomegalovirus infection associated with esophagogastritis and terminal ileitis. The patient was HTLV-1-positive and was diagnosed with smoldering adult T cell leukemia (ATL). High levels of serum soluble IL-2 receptor (sIL-2R; 4,304 U/mL) and an increased percentage of CD4+CD25+ T cells (75.5%) in peripheral blood were also detected. The second patient was a 78-year-old female, a known asymptomatic HTLV-1 carrier, who presented with persistent herpes zoster, followed by Pneumocystis jirovecii pneumonia. Disease progression of smoldering ATL along opportunistic infections was observed with very high levels of serum sIL-2R (14,058 U/mL) and an increased percentage of CD4+CD25+ T cells (87.2%) in peripheral blood. In patients with suspected opportunistic infections, both HTLV-1 and HIV should be considered. In HTLV-1-positive patients, an increase in the CD4+CD25+ T cell subset may have its value as a prognostic marker.http://dx.doi.org/10.1155/2015/943867 |
| spellingShingle | Toshiki Tanaka Toshio Sekioka Masakatsu Usui Shinsaku Imashuku Opportunistic Infections in Patients with HTLV-1 Infection Case Reports in Hematology |
| title | Opportunistic Infections in Patients with HTLV-1 Infection |
| title_full | Opportunistic Infections in Patients with HTLV-1 Infection |
| title_fullStr | Opportunistic Infections in Patients with HTLV-1 Infection |
| title_full_unstemmed | Opportunistic Infections in Patients with HTLV-1 Infection |
| title_short | Opportunistic Infections in Patients with HTLV-1 Infection |
| title_sort | opportunistic infections in patients with htlv 1 infection |
| url | http://dx.doi.org/10.1155/2015/943867 |
| work_keys_str_mv | AT toshikitanaka opportunisticinfectionsinpatientswithhtlv1infection AT toshiosekioka opportunisticinfectionsinpatientswithhtlv1infection AT masakatsuusui opportunisticinfectionsinpatientswithhtlv1infection AT shinsakuimashuku opportunisticinfectionsinpatientswithhtlv1infection |