Endolysosomal processing of neuron-derived signaling lipids regulates autophagy and lipid droplet degradation in astrocytes

Abstract Dynamic regulation of metabolic activities in astrocytes is critical to meeting the demands of other brain cells. During neuronal stress, lipids are transferred from neurons to astrocytes, where they are stored in lipid droplets (LDs). However, it is not clear whether and how neuron-derived...

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Bibliographic Details
Main Authors: Jagannatham Naidu Bhupana, Angelid Pabon, Ho Hang Leung, Mohamed Asik Rajmohamed, Sang Hoon Kim, Yan Tong, Mi-Hyeon Jang, Ching-On Wong
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60402-3
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