Biological Strategies to Enhance Healing of the Avascular Area of the Meniscus
Meniscal injuries in the vascularized peripheral part of the meniscus have a better healing potential than tears in the central avascular zone because meniscal healing principally depends on its vascular supply. Several biological strategies have been proposed to enhance healing of the avascular are...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2012/528359 |
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| author | Umile Giuseppe Longo Stefano Campi Giovanni Romeo Filippo Spiezia Nicola Maffulli Vincenzo Denaro |
| author_facet | Umile Giuseppe Longo Stefano Campi Giovanni Romeo Filippo Spiezia Nicola Maffulli Vincenzo Denaro |
| author_sort | Umile Giuseppe Longo |
| collection | DOAJ |
| description | Meniscal injuries in the vascularized peripheral part of the meniscus have a better healing potential than tears in the central avascular zone because meniscal healing principally depends on its vascular supply. Several biological strategies have been proposed to enhance healing of the avascular area of the meniscus: abrasion therapy, fibrin clot, organ culture, cell therapy, and applications of growth factors. However, data are too heterogeneous to achieve definitive conclusions on the use of these techniques for routine management of meniscal lesions. Although most preclinical and clinical studies are very promising, they are still at an experimental stage. More prospective randomised controlled trials are needed to compare the different techniques for clinical results, applicability, and cost-effectiveness. |
| format | Article |
| id | doaj-art-d2b7ac014ffb43a1bba55f38380777d7 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-d2b7ac014ffb43a1bba55f38380777d72025-02-03T01:23:49ZengWileyStem Cells International1687-966X1687-96782012-01-01201210.1155/2012/528359528359Biological Strategies to Enhance Healing of the Avascular Area of the MeniscusUmile Giuseppe Longo0Stefano Campi1Giovanni Romeo2Filippo Spiezia3Nicola Maffulli4Vincenzo Denaro5Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo, 200, 00128 Rome, ItalyDepartment of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo, 200, 00128 Rome, ItalyDepartment of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo, 200, 00128 Rome, ItalyDepartment of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo, 200, 00128 Rome, ItalyCentre for Sports and Exercise Medicine, Barts and The London School of Medicine and Dentistry, Mile End Hospital, 275 Bancroft Road, London E1 4DG, UKDepartment of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo, 200, 00128 Rome, ItalyMeniscal injuries in the vascularized peripheral part of the meniscus have a better healing potential than tears in the central avascular zone because meniscal healing principally depends on its vascular supply. Several biological strategies have been proposed to enhance healing of the avascular area of the meniscus: abrasion therapy, fibrin clot, organ culture, cell therapy, and applications of growth factors. However, data are too heterogeneous to achieve definitive conclusions on the use of these techniques for routine management of meniscal lesions. Although most preclinical and clinical studies are very promising, they are still at an experimental stage. More prospective randomised controlled trials are needed to compare the different techniques for clinical results, applicability, and cost-effectiveness.http://dx.doi.org/10.1155/2012/528359 |
| spellingShingle | Umile Giuseppe Longo Stefano Campi Giovanni Romeo Filippo Spiezia Nicola Maffulli Vincenzo Denaro Biological Strategies to Enhance Healing of the Avascular Area of the Meniscus Stem Cells International |
| title | Biological Strategies to Enhance Healing of the Avascular Area of the Meniscus |
| title_full | Biological Strategies to Enhance Healing of the Avascular Area of the Meniscus |
| title_fullStr | Biological Strategies to Enhance Healing of the Avascular Area of the Meniscus |
| title_full_unstemmed | Biological Strategies to Enhance Healing of the Avascular Area of the Meniscus |
| title_short | Biological Strategies to Enhance Healing of the Avascular Area of the Meniscus |
| title_sort | biological strategies to enhance healing of the avascular area of the meniscus |
| url | http://dx.doi.org/10.1155/2012/528359 |
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