DNA Copy Number Changes at 8q11–24 in Metastasized Colorectal Cancer

DNA Copy Number Changes at 8q11–24 in Metastasized Colorectal Cancer

Background: C-Myc, a well-known oncogene located on 8q24.12–q24.23, is often amplified and over-expressed in both primary and metastasizing colorectal cancer. In addition, PRL-3 (also known as PTP4A3), a tyrosine phosphatase located on 8q24.3, is amplified in colorectal cancer metastasis. Beside PRL...

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Main Authors: T. E. Buffart, J. Coffa, M. A. J. A. Hermsen, B. Carvalho, J. R. M. van der Sijp, B. Ylstra, G. Pals, J. P. Schouten, G. A. Meijer
Format: Article
Language:English
Published: Wiley 2005-01-01
Series:Cellular Oncology
Online Access:http://dx.doi.org/10.1155/2005/401607
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