Aniline TFPA enhances camptothecin-induced anti-NSCLC by modulating oxidative stress and impairing autophagy

Aniline TFPA enhances camptothecin-induced anti-NSCLC by modulating oxidative stress and impairing autophagy

Abstract Background Camptothecin (CPT) derivatives are widely used in cancer therapies, but their efficacy can be attenuated by resistance mechanisms such as autophagy. We recently showed that the aniline compound 4-[4-(4-aminophenoxy)-2,3,5,6-tetrafluorophenoxy] aniline (TFPA) can potently increase...

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Main Authors: Han-Lin Chou, I-Ling Lin, Yei-Tsung Chen, Wen-Tsan Chang, Ann Yu, Wei-Chun Chen, Chang-Yi Wu, Shean-Jaw Chiou, Chih-Wen Shu, Chien-Chih Chiu, Pei-Feng Liu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cancer Cell International
Subjects:
Lung cancer
Autophagy impairment
CPT
Aniline
TFPA
Oxidative stress
Online Access:https://doi.org/10.1186/s12935-025-03657-6
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