Exploring Seipin: From Biochemistry to Bioinformatics Predictions
Seipin is a nonenzymatic protein encoded by the BSCL2 gene. It is involved in lipodystrophy and seipinopathy diseases. Named in 2001, all seipin functions are still far from being understood. Therefore, we reviewed much of the research, trying to find a pattern that could explain commonly observed f...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2018/5207608 |
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| _version_ | 1832552597047738368 |
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| author | Aquiles Sales Craveiro Sarmento Lázaro Batista de Azevedo Medeiros Lucymara Fassarella Agnez-Lima Josivan Gomes Lima Julliane Tamara Araújo de Melo Campos |
| author_facet | Aquiles Sales Craveiro Sarmento Lázaro Batista de Azevedo Medeiros Lucymara Fassarella Agnez-Lima Josivan Gomes Lima Julliane Tamara Araújo de Melo Campos |
| author_sort | Aquiles Sales Craveiro Sarmento |
| collection | DOAJ |
| description | Seipin is a nonenzymatic protein encoded by the BSCL2 gene. It is involved in lipodystrophy and seipinopathy diseases. Named in 2001, all seipin functions are still far from being understood. Therefore, we reviewed much of the research, trying to find a pattern that could explain commonly observed features of seipin expression disorders. Likewise, this review shows how this protein seems to have tissue-specific functions. In an integrative view, we conclude by proposing a theoretical model to explain how seipin might be involved in the triacylglycerol synthesis pathway. |
| format | Article |
| id | doaj-art-d2a440ecee854ee8b36efd6a0a56b2f2 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-d2a440ecee854ee8b36efd6a0a56b2f22025-02-03T05:58:17ZengWileyInternational Journal of Cell Biology1687-88761687-88842018-01-01201810.1155/2018/52076085207608Exploring Seipin: From Biochemistry to Bioinformatics PredictionsAquiles Sales Craveiro Sarmento0Lázaro Batista de Azevedo Medeiros1Lucymara Fassarella Agnez-Lima2Josivan Gomes Lima3Julliane Tamara Araújo de Melo Campos4Laboratório de Biologia Molecular e Genômica, Departamento de Biologia Celular e Genética, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, RN, BrazilLaboratório de Biologia Molecular e Genômica, Departamento de Biologia Celular e Genética, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, RN, BrazilLaboratório de Biologia Molecular e Genômica, Departamento de Biologia Celular e Genética, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, RN, BrazilDepartamento de Medicina Clínica, Hospital Universitário Onofre Lopes, Universidade Federal do Rio Grande do Norte, Natal, RN, BrazilLaboratório de Biologia Molecular e Genômica, Departamento de Biologia Celular e Genética, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, RN, BrazilSeipin is a nonenzymatic protein encoded by the BSCL2 gene. It is involved in lipodystrophy and seipinopathy diseases. Named in 2001, all seipin functions are still far from being understood. Therefore, we reviewed much of the research, trying to find a pattern that could explain commonly observed features of seipin expression disorders. Likewise, this review shows how this protein seems to have tissue-specific functions. In an integrative view, we conclude by proposing a theoretical model to explain how seipin might be involved in the triacylglycerol synthesis pathway.http://dx.doi.org/10.1155/2018/5207608 |
| spellingShingle | Aquiles Sales Craveiro Sarmento Lázaro Batista de Azevedo Medeiros Lucymara Fassarella Agnez-Lima Josivan Gomes Lima Julliane Tamara Araújo de Melo Campos Exploring Seipin: From Biochemistry to Bioinformatics Predictions International Journal of Cell Biology |
| title | Exploring Seipin: From Biochemistry to Bioinformatics Predictions |
| title_full | Exploring Seipin: From Biochemistry to Bioinformatics Predictions |
| title_fullStr | Exploring Seipin: From Biochemistry to Bioinformatics Predictions |
| title_full_unstemmed | Exploring Seipin: From Biochemistry to Bioinformatics Predictions |
| title_short | Exploring Seipin: From Biochemistry to Bioinformatics Predictions |
| title_sort | exploring seipin from biochemistry to bioinformatics predictions |
| url | http://dx.doi.org/10.1155/2018/5207608 |
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