Clinical Significance of Lymph Node Micrometastasis in pN0 Gastric Cancer Patients
Purpose. To investigate the relationship between lymph node micrometastasis (LNMM) and clinicopathological factors and to evaluate the prognostic effects of LNMM in pN0 gastric cancer (GC) patients. Methods. One hundred and seventy-two GC patients who received radical gastrectomy with D2 lymph node...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2021/6854646 |
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| author | Yu Li Dongsheng Wang Yi Li Xiaodong Liu Dong Chen Chentong Yuan Yanbing Zhou |
| author_facet | Yu Li Dongsheng Wang Yi Li Xiaodong Liu Dong Chen Chentong Yuan Yanbing Zhou |
| author_sort | Yu Li |
| collection | DOAJ |
| description | Purpose. To investigate the relationship between lymph node micrometastasis (LNMM) and clinicopathological factors and to evaluate the prognostic effects of LNMM in pN0 gastric cancer (GC) patients. Methods. One hundred and seventy-two GC patients who received radical gastrectomy with D2 lymph node dissection were enrolled in the present study. 1371 negative lymph nodes from level 2 station confirmed by pathology were examined. The LNMM was diagnosed by telomeric repeat amplification protocol/enzyme-linked immunosorbent assay (TRAP-ELISA). The relationship between clinicopathological factors and LNMM was investigated by multivariate analysis. Survival analysis was performed to evaluate the effects of LNMM on prognosis. Results. LNMM was detected in 423 lymph nodes from 72 patients. The results showed that invasion depth (OR=3.755, P=0.004), TNM staging (OR=3.152, P=0.002), lymphatic invasion (OR=2.178, P=0.009), and tumor differentiation (OR=1.266, P=0.013) were independent risk factors associated with LNMM. Survival analysis showed that patients with LNMM had significantly worse 5-year survival compared with those without LNMM (42% vs. 76.4%, P<0.05). Multivariate analysis demonstrated that LNMM, tumor size, Lauren type, invasion depth, and lymphatic invasion (P<0.05) were independently factors associated with 5-year survival. Conclusions. The findings showed that tumor invasion depth, TNM staging, lymphatic invasion, and tumor differentiation were independent risk factors associated with LNMM occurrence. Moreover, LNMM is a clinically negative prognostic factor in pN0 GC patients. |
| format | Article |
| id | doaj-art-d2a0425e57df422f9b8b81239595fe14 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-d2a0425e57df422f9b8b81239595fe142025-02-03T01:29:19ZengWileyGastroenterology Research and Practice1687-61211687-630X2021-01-01202110.1155/2021/68546466854646Clinical Significance of Lymph Node Micrometastasis in pN0 Gastric Cancer PatientsYu Li0Dongsheng Wang1Yi Li2Xiaodong Liu3Dong Chen4Chentong Yuan5Yanbing Zhou6Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaPurpose. To investigate the relationship between lymph node micrometastasis (LNMM) and clinicopathological factors and to evaluate the prognostic effects of LNMM in pN0 gastric cancer (GC) patients. Methods. One hundred and seventy-two GC patients who received radical gastrectomy with D2 lymph node dissection were enrolled in the present study. 1371 negative lymph nodes from level 2 station confirmed by pathology were examined. The LNMM was diagnosed by telomeric repeat amplification protocol/enzyme-linked immunosorbent assay (TRAP-ELISA). The relationship between clinicopathological factors and LNMM was investigated by multivariate analysis. Survival analysis was performed to evaluate the effects of LNMM on prognosis. Results. LNMM was detected in 423 lymph nodes from 72 patients. The results showed that invasion depth (OR=3.755, P=0.004), TNM staging (OR=3.152, P=0.002), lymphatic invasion (OR=2.178, P=0.009), and tumor differentiation (OR=1.266, P=0.013) were independent risk factors associated with LNMM. Survival analysis showed that patients with LNMM had significantly worse 5-year survival compared with those without LNMM (42% vs. 76.4%, P<0.05). Multivariate analysis demonstrated that LNMM, tumor size, Lauren type, invasion depth, and lymphatic invasion (P<0.05) were independently factors associated with 5-year survival. Conclusions. The findings showed that tumor invasion depth, TNM staging, lymphatic invasion, and tumor differentiation were independent risk factors associated with LNMM occurrence. Moreover, LNMM is a clinically negative prognostic factor in pN0 GC patients.http://dx.doi.org/10.1155/2021/6854646 |
| spellingShingle | Yu Li Dongsheng Wang Yi Li Xiaodong Liu Dong Chen Chentong Yuan Yanbing Zhou Clinical Significance of Lymph Node Micrometastasis in pN0 Gastric Cancer Patients Gastroenterology Research and Practice |
| title | Clinical Significance of Lymph Node Micrometastasis in pN0 Gastric Cancer Patients |
| title_full | Clinical Significance of Lymph Node Micrometastasis in pN0 Gastric Cancer Patients |
| title_fullStr | Clinical Significance of Lymph Node Micrometastasis in pN0 Gastric Cancer Patients |
| title_full_unstemmed | Clinical Significance of Lymph Node Micrometastasis in pN0 Gastric Cancer Patients |
| title_short | Clinical Significance of Lymph Node Micrometastasis in pN0 Gastric Cancer Patients |
| title_sort | clinical significance of lymph node micrometastasis in pn0 gastric cancer patients |
| url | http://dx.doi.org/10.1155/2021/6854646 |
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