Achieving Complete Remission of Hepatocellular Carcinoma: A Significant Predictor for Recurrence-Free Survival after Liver Transplantation
Background. Liver transplantation (LT) is a curative treatment for hepatocellular carcinoma (HCC) and the underlying primary liver disease; however, tumor recurrence is still a major issue. Therefore, the aim of this study was to assess predictors and risk factors for HCC recurrence after LT in pati...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2019/5796074 |
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| author | Christin Bürger Miriam Maschmeier Anna Hüsing-Kabar Christian Wilms Michael Köhler Martina Schmidt Hartmut H. Schmidt Iyad Kabar |
| author_facet | Christin Bürger Miriam Maschmeier Anna Hüsing-Kabar Christian Wilms Michael Köhler Martina Schmidt Hartmut H. Schmidt Iyad Kabar |
| author_sort | Christin Bürger |
| collection | DOAJ |
| description | Background. Liver transplantation (LT) is a curative treatment for hepatocellular carcinoma (HCC) and the underlying primary liver disease; however, tumor recurrence is still a major issue. Therefore, the aim of this study was to assess predictors and risk factors for HCC recurrence after LT in patients within and outside the Milan criteria with a special focus on the impact of different bridging strategies. Methods. All patients who underwent LT for HCC between 07/2002 and 09/2016 at the University Hospital of Muenster were consecutively included in this retrospective study. Database research was performed and a multivariable regression analysis was conducted to explore potential risk factors for HCC recurrence. Results. A total of 82 patients were eligible for the statistical analysis. Independent of bridging strategy, achieving complete remission (CR) was significantly associated with a lower risk for tumor recurrence (p = 0.029; OR = 0.426, 95% CI 0.198-0.918). A maximal diameter of lesion < 3 cm was also associated with lower recurrence rates (p = 0.040; OR = 0.140, 95% CI 0.022-0.914). Vascular invasion proved to be an independent risk factor for HCC recurrence (p = 0.004; OR = 11.357, 95% CI 2.142-60.199). Conclusion. Achieving CR prior to LT results in a significant risk reduction of HCC recurrence after LT independent of the treatment modalities applied. |
| format | Article |
| id | doaj-art-d28d80d3074a47e2aff67c606b6d5b93 |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-d28d80d3074a47e2aff67c606b6d5b932025-02-03T01:10:56ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972019-01-01201910.1155/2019/57960745796074Achieving Complete Remission of Hepatocellular Carcinoma: A Significant Predictor for Recurrence-Free Survival after Liver TransplantationChristin Bürger0Miriam Maschmeier1Anna Hüsing-Kabar2Christian Wilms3Michael Köhler4Martina Schmidt5Hartmut H. Schmidt6Iyad Kabar7Department of Medicine B for Gastroenterology and Hepatology, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Medicine B for Gastroenterology and Hepatology, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Medicine B for Gastroenterology and Hepatology, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Medicine B for Gastroenterology and Hepatology, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Clinical Radiology, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Medicine B for Gastroenterology and Hepatology, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Medicine B for Gastroenterology and Hepatology, University Hospital Muenster, 48149 Muenster, GermanyDepartment of Medicine B for Gastroenterology and Hepatology, University Hospital Muenster, 48149 Muenster, GermanyBackground. Liver transplantation (LT) is a curative treatment for hepatocellular carcinoma (HCC) and the underlying primary liver disease; however, tumor recurrence is still a major issue. Therefore, the aim of this study was to assess predictors and risk factors for HCC recurrence after LT in patients within and outside the Milan criteria with a special focus on the impact of different bridging strategies. Methods. All patients who underwent LT for HCC between 07/2002 and 09/2016 at the University Hospital of Muenster were consecutively included in this retrospective study. Database research was performed and a multivariable regression analysis was conducted to explore potential risk factors for HCC recurrence. Results. A total of 82 patients were eligible for the statistical analysis. Independent of bridging strategy, achieving complete remission (CR) was significantly associated with a lower risk for tumor recurrence (p = 0.029; OR = 0.426, 95% CI 0.198-0.918). A maximal diameter of lesion < 3 cm was also associated with lower recurrence rates (p = 0.040; OR = 0.140, 95% CI 0.022-0.914). Vascular invasion proved to be an independent risk factor for HCC recurrence (p = 0.004; OR = 11.357, 95% CI 2.142-60.199). Conclusion. Achieving CR prior to LT results in a significant risk reduction of HCC recurrence after LT independent of the treatment modalities applied.http://dx.doi.org/10.1155/2019/5796074 |
| spellingShingle | Christin Bürger Miriam Maschmeier Anna Hüsing-Kabar Christian Wilms Michael Köhler Martina Schmidt Hartmut H. Schmidt Iyad Kabar Achieving Complete Remission of Hepatocellular Carcinoma: A Significant Predictor for Recurrence-Free Survival after Liver Transplantation Canadian Journal of Gastroenterology and Hepatology |
| title | Achieving Complete Remission of Hepatocellular Carcinoma: A Significant Predictor for Recurrence-Free Survival after Liver Transplantation |
| title_full | Achieving Complete Remission of Hepatocellular Carcinoma: A Significant Predictor for Recurrence-Free Survival after Liver Transplantation |
| title_fullStr | Achieving Complete Remission of Hepatocellular Carcinoma: A Significant Predictor for Recurrence-Free Survival after Liver Transplantation |
| title_full_unstemmed | Achieving Complete Remission of Hepatocellular Carcinoma: A Significant Predictor for Recurrence-Free Survival after Liver Transplantation |
| title_short | Achieving Complete Remission of Hepatocellular Carcinoma: A Significant Predictor for Recurrence-Free Survival after Liver Transplantation |
| title_sort | achieving complete remission of hepatocellular carcinoma a significant predictor for recurrence free survival after liver transplantation |
| url | http://dx.doi.org/10.1155/2019/5796074 |
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