Structural insight into the self-activation and G-protein coupling of P2Y2 receptor

Structural insight into the self-activation and G-protein coupling of P2Y2 receptor

Abstract Purinergic P2Y2 receptor (P2Y2R) represents a typically extracellular ATP and UTP sensor for mediating purinergic signaling. Despite its importance as a pharmacological target, the molecular mechanisms underlying ligand recognition and G-protein coupling have remained elusive due to lack of...

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Main Authors: Baoliang Lan, Shuhao Zhang, Kai Chen, Shengjie Dai, Jiaqi Fei, Kaixuan Gao, Xiaoou Sun, Bin Lin, Xiangyu Liu
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-025-00797-x
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https://doi.org/10.1038/s41421-025-00797-x

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