Taste hedonics influence the disposition of fat by modulating gastric emptying in rats.
We investigated how preferred and nonpreferred tastes influence the disposition of fat. Adult male Sprague Dawley rats were infused with 5 ml of 20% intralipid through an intragastric catheter and with 0.3 ml of a taste solution through an intraoral catheter. At 120 min postinfusion, plasma concentr...
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090717&type=printable |
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| author | Katsuyoshi Saitou John N Lees Michael G Tordoff |
| author_facet | Katsuyoshi Saitou John N Lees Michael G Tordoff |
| author_sort | Katsuyoshi Saitou |
| collection | DOAJ |
| description | We investigated how preferred and nonpreferred tastes influence the disposition of fat. Adult male Sprague Dawley rats were infused with 5 ml of 20% intralipid through an intragastric catheter and with 0.3 ml of a taste solution through an intraoral catheter. At 120 min postinfusion, plasma concentrations of fat fuels (triglycerides and non-esterified fatty acids) were either unchanged or slightly higher after rats tasted a preferred sweet taste solution (0.125% saccharin +3% glucose) than after they tasted water. They were markedly lower after rats tasted a non-preferred solution-either a bitter solution (0.15% quinine hydrochloride) or a sweet solution that had previously been the conditioned stimulus for lithium-induced taste aversion. The distribution of 14C-triolein mixed with the gastric load was determined at 4 h postinfusion. Rats that received a non-preferred bitter taste had significantly more 14C remaining in the stomach than did those that received a preferred sweet taste. These results suggest that taste hedonics--either unconditioned or conditioned aversive tastes--influence fat disposition by altering gastric emptying. |
| format | Article |
| id | doaj-art-d285a03d2ebd4e85bd57c6bc9b36feb9 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-d285a03d2ebd4e85bd57c6bc9b36feb92025-08-20T03:01:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e9071710.1371/journal.pone.0090717Taste hedonics influence the disposition of fat by modulating gastric emptying in rats.Katsuyoshi SaitouJohn N LeesMichael G TordoffWe investigated how preferred and nonpreferred tastes influence the disposition of fat. Adult male Sprague Dawley rats were infused with 5 ml of 20% intralipid through an intragastric catheter and with 0.3 ml of a taste solution through an intraoral catheter. At 120 min postinfusion, plasma concentrations of fat fuels (triglycerides and non-esterified fatty acids) were either unchanged or slightly higher after rats tasted a preferred sweet taste solution (0.125% saccharin +3% glucose) than after they tasted water. They were markedly lower after rats tasted a non-preferred solution-either a bitter solution (0.15% quinine hydrochloride) or a sweet solution that had previously been the conditioned stimulus for lithium-induced taste aversion. The distribution of 14C-triolein mixed with the gastric load was determined at 4 h postinfusion. Rats that received a non-preferred bitter taste had significantly more 14C remaining in the stomach than did those that received a preferred sweet taste. These results suggest that taste hedonics--either unconditioned or conditioned aversive tastes--influence fat disposition by altering gastric emptying.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090717&type=printable |
| spellingShingle | Katsuyoshi Saitou John N Lees Michael G Tordoff Taste hedonics influence the disposition of fat by modulating gastric emptying in rats. PLoS ONE |
| title | Taste hedonics influence the disposition of fat by modulating gastric emptying in rats. |
| title_full | Taste hedonics influence the disposition of fat by modulating gastric emptying in rats. |
| title_fullStr | Taste hedonics influence the disposition of fat by modulating gastric emptying in rats. |
| title_full_unstemmed | Taste hedonics influence the disposition of fat by modulating gastric emptying in rats. |
| title_short | Taste hedonics influence the disposition of fat by modulating gastric emptying in rats. |
| title_sort | taste hedonics influence the disposition of fat by modulating gastric emptying in rats |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090717&type=printable |
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