Fluorescence Lifetime Imaging for Quantification of Targeted Drug Delivery in Varying Tumor Microenvironments

Fluorescence Lifetime Imaging for Quantification of Targeted Drug Delivery in Varying Tumor Microenvironments

Abstract Trastuzumab (TZM) is a monoclonal antibody that targets the human epidermal growth factor receptor 2 (HER2) and is clinically used for the treatment of HER2‐positive breast tumors. However, the tumor microenvironment can limit the access of TZM to the HER2 targets across the whole tumor and...

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Bibliographic Details
Main Authors: Amit Verma, Vikas Pandey, Catherine Sherry, Taylor Humphrey, Christopher James, Kailie Matteson, Jason T. Smith, Alena Rudkouskaya, Xavier Intes, Margarida Barroso
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
breast tumor
fluorescence lifetime imaging
FRET
HER2
Trastuzumab
target engagement
Online Access:https://doi.org/10.1002/advs.202403253
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