Primary thyroid gland myxofibrosarcoma: a case report and review of the literature

Abstract Background Myxofibrosarcoma is a common soft tissue sarcoma of the extremities, which occurs very rarely in the thyroid gland. Case presentation We report the case of a 61-year-old male who presented with a swelling of the left side of the neck and a newly emerged hoarseness. Ultrasound dep...

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Main Authors: Maria Chara Stylianidi, Lena Haeberle, Matthias Schott, Yuriko Mori, Christina Antke, Frederick Lars Giesel, Gerald Antoch, Irene Esposito, Wolfram Trudo Knoefel, Andreas Krieg
Format: Article
Language:English
Published: Japan Surgical Society 2022-07-01
Series:Surgical Case Reports
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Online Access:https://doi.org/10.1186/s40792-022-01496-5
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Summary:Abstract Background Myxofibrosarcoma is a common soft tissue sarcoma of the extremities, which occurs very rarely in the thyroid gland. Case presentation We report the case of a 61-year-old male who presented with a swelling of the left side of the neck and a newly emerged hoarseness. Ultrasound depicted a hypoechoic thyroid nodule with microcalcifications that was highly suspicious for malignancy. He underwent a left hemithyroidectomy. Histopathological examination and immunohistochemical studies revealed a myxofibrosarcoma of the thyroid gland. Conclusion Myxofibrosarcoma of the thyroid gland is extremely rare. The diagnosis is based on histopathological features. Radical surgery achieving tumor-free resection margins remains the only chance for cure. However, the role of radiotherapy and/or chemotherapy is still under debate. Due to their high tendency for locoregional recurrence, a close follow-up after surgery is mandatory.
ISSN:2198-7793