Hsp70 and Its Molecular Role in Nervous System Diseases
Heat shock proteins (HSPs) are induced in response to many injuries including stroke, neurodegenerative disease, epilepsy, and trauma. The overexpression of one HSP in particular, Hsp70, serves a protective role in several different models of nervous system injury, but has also been linked to a dele...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2011/618127 |
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| author | Giuseppina Turturici Gabriella Sconzo Fabiana Geraci |
| author_facet | Giuseppina Turturici Gabriella Sconzo Fabiana Geraci |
| author_sort | Giuseppina Turturici |
| collection | DOAJ |
| description | Heat shock proteins (HSPs) are induced in response to many injuries including stroke, neurodegenerative disease, epilepsy, and trauma. The overexpression of one HSP in particular, Hsp70, serves a protective role in several different models of nervous system injury, but has also been linked to a deleterious role in some diseases. Hsp70 functions as a chaperone and protects neurons from protein aggregation and toxicity (Parkinson disease, Alzheimer disease, polyglutamine diseases, and amyotrophic lateral sclerosis), protects cells from apoptosis (Parkinson disease), is a stress marker (temporal lobe epilepsy), protects cells from inflammation (cerebral ischemic injury), has an adjuvant role in antigen presentation and is involved in the immune response in autoimmune disease (multiple sclerosis). The worldwide incidence of neurodegenerative diseases is high. As neurodegenerative diseases disproportionately affect older individuals, disease-related morbidity has increased along with the general increase in longevity. An understanding of the underlying mechanisms that lead to neurodegeneration is key to identifying methods of prevention and treatment. Investigators have observed protective effects of HSPs induced by preconditioning, overexpression, or drugs in a variety of models of brain disease. Experimental data suggest that manipulation of the cellular stress response may offer strategies to protect the brain during progression of neurodegenerative disease. |
| format | Article |
| id | doaj-art-d269952b501b4b63addef713b6cb8448 |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-d269952b501b4b63addef713b6cb84482025-02-03T06:44:44ZengWileyBiochemistry Research International2090-22472090-22552011-01-01201110.1155/2011/618127618127Hsp70 and Its Molecular Role in Nervous System DiseasesGiuseppina Turturici0Gabriella Sconzo1Fabiana Geraci2Department of Cellular and Developmental Biology, University of Palermo, Viale delle Scienze, 90128 Palermo, ItalyDepartment of Cellular and Developmental Biology, University of Palermo, Viale delle Scienze, 90128 Palermo, ItalyDepartment of Cellular and Developmental Biology, University of Palermo, Viale delle Scienze, 90128 Palermo, ItalyHeat shock proteins (HSPs) are induced in response to many injuries including stroke, neurodegenerative disease, epilepsy, and trauma. The overexpression of one HSP in particular, Hsp70, serves a protective role in several different models of nervous system injury, but has also been linked to a deleterious role in some diseases. Hsp70 functions as a chaperone and protects neurons from protein aggregation and toxicity (Parkinson disease, Alzheimer disease, polyglutamine diseases, and amyotrophic lateral sclerosis), protects cells from apoptosis (Parkinson disease), is a stress marker (temporal lobe epilepsy), protects cells from inflammation (cerebral ischemic injury), has an adjuvant role in antigen presentation and is involved in the immune response in autoimmune disease (multiple sclerosis). The worldwide incidence of neurodegenerative diseases is high. As neurodegenerative diseases disproportionately affect older individuals, disease-related morbidity has increased along with the general increase in longevity. An understanding of the underlying mechanisms that lead to neurodegeneration is key to identifying methods of prevention and treatment. Investigators have observed protective effects of HSPs induced by preconditioning, overexpression, or drugs in a variety of models of brain disease. Experimental data suggest that manipulation of the cellular stress response may offer strategies to protect the brain during progression of neurodegenerative disease.http://dx.doi.org/10.1155/2011/618127 |
| spellingShingle | Giuseppina Turturici Gabriella Sconzo Fabiana Geraci Hsp70 and Its Molecular Role in Nervous System Diseases Biochemistry Research International |
| title | Hsp70 and Its Molecular Role in Nervous System Diseases |
| title_full | Hsp70 and Its Molecular Role in Nervous System Diseases |
| title_fullStr | Hsp70 and Its Molecular Role in Nervous System Diseases |
| title_full_unstemmed | Hsp70 and Its Molecular Role in Nervous System Diseases |
| title_short | Hsp70 and Its Molecular Role in Nervous System Diseases |
| title_sort | hsp70 and its molecular role in nervous system diseases |
| url | http://dx.doi.org/10.1155/2011/618127 |
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