Pre T-Cell Receptor Alpha (pTα) Expression Patterns and Functional Analysis in Human T-Cell Lymphoblastic Leukemia
Background: The pTα/preTCR regulates the β-selection, a crucial T-cell developmental checkpoint, providing a most potent survival advantage to thymocytes mediated by the src-kinase p56Lck.
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.3233/CLO-2009-0500 |
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| _version_ | 1832563116704006144 |
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| author | Philipp Ivanyi Michael Morgan Wenji Piao Sya N. Ukena Klaus Steube Arnold Ganser Anke Franzke |
| author_facet | Philipp Ivanyi Michael Morgan Wenji Piao Sya N. Ukena Klaus Steube Arnold Ganser Anke Franzke |
| author_sort | Philipp Ivanyi |
| collection | DOAJ |
| description | Background: The pTα/preTCR regulates the β-selection, a crucial T-cell developmental checkpoint, providing a most potent survival advantage to thymocytes mediated by the src-kinase p56Lck. |
| format | Article |
| id | doaj-art-d25405fcf9544658a934f0a543ad74a4 |
| institution | Kabale University |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-d25405fcf9544658a934f0a543ad74a42025-02-03T01:20:57ZengWileyCellular Oncology1570-58701875-86062010-01-01321-210110810.3233/CLO-2009-0500Pre T-Cell Receptor Alpha (pTα) Expression Patterns and Functional Analysis in Human T-Cell Lymphoblastic LeukemiaPhilipp Ivanyi0Michael Morgan1Wenji Piao2Sya N. Ukena3Klaus Steube4Arnold Ganser5Anke Franzke6Clinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Medizinische Hochschule Hannover, Hannover, GermanyClinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Medizinische Hochschule Hannover, Hannover, GermanyClinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Medizinische Hochschule Hannover, Hannover, GermanyClinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Medizinische Hochschule Hannover, Hannover, GermanyDSMZ, German Collection of Microorganisms and Cell Cultures, Braunschweig, GermanyClinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Medizinische Hochschule Hannover, Hannover, GermanyClinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Medizinische Hochschule Hannover, Hannover, GermanyBackground: The pTα/preTCR regulates the β-selection, a crucial T-cell developmental checkpoint, providing a most potent survival advantage to thymocytes mediated by the src-kinase p56Lck.http://dx.doi.org/10.3233/CLO-2009-0500 |
| spellingShingle | Philipp Ivanyi Michael Morgan Wenji Piao Sya N. Ukena Klaus Steube Arnold Ganser Anke Franzke Pre T-Cell Receptor Alpha (pTα) Expression Patterns and Functional Analysis in Human T-Cell Lymphoblastic Leukemia Cellular Oncology |
| title | Pre T-Cell Receptor Alpha (pTα) Expression Patterns and Functional Analysis in Human T-Cell Lymphoblastic Leukemia |
| title_full | Pre T-Cell Receptor Alpha (pTα) Expression Patterns and Functional Analysis in Human T-Cell Lymphoblastic Leukemia |
| title_fullStr | Pre T-Cell Receptor Alpha (pTα) Expression Patterns and Functional Analysis in Human T-Cell Lymphoblastic Leukemia |
| title_full_unstemmed | Pre T-Cell Receptor Alpha (pTα) Expression Patterns and Functional Analysis in Human T-Cell Lymphoblastic Leukemia |
| title_short | Pre T-Cell Receptor Alpha (pTα) Expression Patterns and Functional Analysis in Human T-Cell Lymphoblastic Leukemia |
| title_sort | pre t cell receptor alpha ptα expression patterns and functional analysis in human t cell lymphoblastic leukemia |
| url | http://dx.doi.org/10.3233/CLO-2009-0500 |
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