Co-differentiation and enrichment of corneal endothelial cells and keratocytes from human pluripotent stem cells

Co-differentiation and enrichment of corneal endothelial cells and keratocytes from human pluripotent stem cells

Abstract Corneal keratocytes (CK) and endothelial cells (CEnC) maintain corneal stromal transparency. Damage to these cell types can lead to visual impairment. Although corneal transplantation is effective, donor shortages limit its availability. Human pluripotent stem cells (hPSC) offer a promising...

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Bibliographic Details
Main Authors: Abhinav Reddy Kethiri, Pyry Grönroos, Ajai Suwaraj Chinnaiah Nagaraj, Heli Skottman
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Cornea
Stroma
Keratocytes
Endothelium
Pluripotent stem cell
Differentiation
Online Access:https://doi.org/10.1038/s41598-025-03509-3
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